Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering , Hubei University , Wuhan 430062 , China.
School of Materials Science & Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China , Tianjin University , Tianjin 300072 , China.
ACS Appl Mater Interfaces. 2019 Apr 24;11(16):15014-15027. doi: 10.1021/acsami.8b22136. Epub 2019 Apr 10.
A bacterial infection on the surface of medical apparatus and instruments as well as artificial implants is threatening human health greatly. Antibiotics and traditional bacterial-killing agents, even silver nanoparticles, can induce bacterial resistance during long-term interaction with bacteria. Hence, rapid surface sterilization and prevention of bacterial infection in the long term are urgent for biomedical devices, especially for artificial implant materials. Herein, a hybridized chitosan (CS), silver nanoparticles (AgNPs), and MnO nanosheets coating was designed on the surface of titanium plates, which can ensure the implants a rapid and highly effective antibacterial efficacy of 99.00% against Staphylococcus aureus ( S. aureus) and 99.25% against Escherichia coli ( E. coli) within 20 min of 808 nm near-infrared light (NIR) irradiation. The exogenous NIR irradiation can trigger the MnO nanosheets to produce enough hyperthermia within 10 min, which can combine with a low concentration of prereleased Ag from the coating to achieve superior antimicrobial efficacy through synergistic effects. In contrast, either prereleased Ag ions or a photothermal effect alone can achieve much lower antibacterial efficiency under the same concentration, i.e., 24.00% and 30.01% for the former and 30.00% and 42.54% for the later toward S. aureus and E. coli, respectively. The possible cytotoxicity of coatings could be eliminated owing to the low concentration of AgNPs and chitosan encapsulation. Thus, the novel bifunctional coating Ag/CS@MnO can exhibit great potential in deep site disinfection of Ti implants through the synergy of prereleased Ag ions and a photothermal effect within a short time.
医疗器械和植入物表面的细菌感染对人类健康构成了极大威胁。抗生素和传统的杀菌剂，甚至是纳米银，在与细菌长期相互作用时会诱导细菌产生耐药性。因此，生物医学器械，尤其是人工植入材料，急需实现快速表面杀菌和长期预防细菌感染。在此，设计了一种壳聚糖（CS）、银纳米颗粒（AgNPs）和 MnO 纳米片的杂化涂层，涂覆在钛板表面，在 808nm 近红外光（NIR）照射下，20min 内可对金黄色葡萄球菌（S. aureus）和大肠杆菌（E. coli）实现 99.00%和 99.25%的快速、高效杀菌效果。外源性 NIR 照射可在 10min 内使 MnO 纳米片产生足够的热，与涂层中预释放的低浓度 Ag 结合，通过协同作用实现优异的抗菌效果。相比之下，在相同浓度下，单独的预释放 Ag 离子或光热效应的抗菌效率要低得多，即分别对金黄色葡萄球菌和大肠杆菌的抗菌效率为 24.00%和 30.01%以及 30.00%和 42.54%。由于 AgNPs 和壳聚糖的低浓度包封，涂层的潜在细胞毒性可以消除。因此，新型双功能涂层 Ag/CS@MnO 通过短时间内预释放 Ag 离子和光热效应的协同作用，在 Ti 植入物的深部部位消毒方面具有巨大的应用潜力。
