Department of Chemistry, University of Delhi, New Delhi, 110007, India.
Department of Immunology and Infectious Disease Biology, CSIR-Institute of Genomics and Integrative Biology, Sukhdev Vihar, New Delhi, 110025, India.
J Nanobiotechnology. 2022 Aug 12;20(1):375. doi: 10.1186/s12951-022-01573-9.
Given the spasmodic increment in antimicrobial resistance (AMR), world is on the verge of "post-antibiotic era". It is anticipated that current SARS-CoV2 pandemic would worsen the situation in future, mainly due to the lack of new/next generation of antimicrobials. In this context, nanoscale materials with antimicrobial potential have a great promise to treat deadly pathogens. These functional materials are uniquely positioned to effectively interfere with the bacterial systems and augment biofilm penetration. Most importantly, the core substance, surface chemistry, shape, and size of nanomaterials define their efficacy while avoiding the development of AMR. Here, we review the mechanisms of AMR and emerging applications of nanoscale functional materials as an excellent substitute for conventional antibiotics. We discuss the potential, promises, challenges and prospects of nanobiotics to combat AMR.
鉴于抗菌药物耐药性（AMR）的间歇性增长，世界正处于“后抗生素时代”的边缘。预计当前的 SARS-CoV2 大流行将在未来使情况恶化，主要是由于缺乏新一代的抗菌药物。在这种情况下，具有抗菌潜力的纳米材料有望成为治疗致命病原体的有效手段。这些功能材料具有独特的优势，可以有效地干扰细菌系统并增强生物膜穿透性。最重要的是，纳米材料的核心物质、表面化学、形状和大小决定了它们的功效，同时避免了 AMR 的发展。在这里，我们回顾了 AMR 的机制以及纳米功能材料作为传统抗生素替代品的新兴应用。我们讨论了纳米抗生素对抗 AMR 的潜力、承诺、挑战和前景。
