胆汁酸诱导大鼠腺胃黏膜中鸟氨酸脱羧酶的活性。
Induction of ornithine decarboxylase activity in rat glandular stomach mucosa by bile acids.
作者信息
Saito T, Kuwahara A, Kobayashi M
出版信息
Jpn J Cancer Res. 1986 Aug;77(8):739-42.
PMID:3093422
Abstract
A single oral instillation of 1.5 g/kg body weight of sodium taurocholate resulted in a rapid, transient stimulation of ornithine decarboxylase activity in rat glandular stomach mucosa, reaching a peak (10 times the control value) 4 to 6 hr after sodium taurocholate treatment and returning to the control level within 48 hr. The degree of stimulation was dose-dependent. Sodium taurodeoxycholate and sodium taurochenodeoxycholate stimulated the enzyme activity similarly.
摘要
经口一次性给予大鼠1.5克/千克体重的牛磺胆酸钠后，大鼠腺胃黏膜中的鸟氨酸脱羧酶活性迅速受到短暂刺激，在给予牛磺胆酸钠4至6小时后达到峰值（为对照值的10倍），并在48小时内恢复到对照水平。刺激程度呈剂量依赖性。牛磺去氧胆酸钠和牛磺鹅去氧胆酸钠对该酶活性的刺激作用相似。
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