1-亚硝基吲哚-3-乙腈对大鼠胃黏膜中鸟氨酸脱羧酶和DNA合成的诱导作用。
Inductions of ornithine decarboxylase and DNA synthesis in rat stomach mucosa by 1-nitrosoindole-3-acetonitrile.
作者信息
Furihata C, Sato Y, Yamakoshi A, Takimoto M, Matsushima T
出版信息
Jpn J Cancer Res. 1987 May;78(5):432-5.
PMID:3112054
Abstract
Administration of 1-nitrosoindole-3-acetonitrile (NIAN) at doses of 40 to 300 mg/kg body weight by gastric intubation to male F344 rats induced up to 100-fold increase in ornithine decarboxylase activity with a maximum after 24 hr and up to 10-fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach. These results suggest that NIAN has potential tumor-promoting activity in carcinogenesis in the glandular stomach.
摘要
通过胃管向雄性F344大鼠给予剂量为40至300mg/kg体重的1-亚硝基吲哚-3-乙腈（NIAN），可使鸟氨酸脱羧酶活性增加高达100倍，在24小时后达到最大值，并且可使胃幽门黏膜中的DNA合成增加高达10倍，在16小时后达到最大值。这些结果表明，NIAN在腺胃致癌过程中具有潜在的促肿瘤活性。
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