阿帕替尼，含4-氨基-3-羟基-5-苯基戊酸的新型酸性蛋白酶抑制剂。
Ahpatinins, new acid protease inhibitors containing 4-amino-3-hydroxy-5-phenylpentanoic acid.
作者信息
Omura S, Imamura N, Kawakita K, Mori Y, Yamazaki Y, Masuma R, Takahashi Y, Tanaka H, Huang L Y, Woodruff H B
出版信息
J Antibiot (Tokyo). 1986 Aug;39(8):1079-85. doi: 10.7164/antibiotics.39.1079.
PMID:3093433
Abstract
A soil isolate, Streptomyces sp. WK-142, was found to produce new acid protease inhibitors, ahpatinins A, B, D, E, F and G active against pepsin and renin. Ahpatinin C was found to be identical with pepstatin A. The structure determinations were based on mass spectral data. Four of the compounds contain the unusual amino acid, 4-amino-3-hydroxy-5-phenylpentanoic acid as a building component.
摘要
从土壤中分离出的链霉菌属菌株Streptomyces sp. WK-142被发现能产生新的酸性蛋白酶抑制剂阿帕廷宁A、B、D、E、F和G，它们对胃蛋白酶和肾素具有活性。发现阿帕廷宁C与胃蛋白酶抑制剂A相同。结构测定基于质谱数据。其中四种化合物含有不寻常的氨基酸4-氨基-3-羟基-5-苯基戊酸作为结构组成部分。
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