Schade John E, King A Douglas
Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Berkeley, California 94710.
J Food Prot. 1984 Dec;47(12):978-995. doi: 10.4315/0362-028X-47.12.978.
Some physical and chemical properties of 40 secondary metabolites produced by Alternaria are tabulated along with literature references. Analytical methodology for three of the several classes of these potential toxins is reviewed in depth, because compounds in these classes are produced in relatively large amounts by many Alternaria and/or are apparently very toxic or mutagenic. Tenuazonic acid, alternariol and alternariol monomethyl ether represent the major toxins in terms of both quantity produced and toxicity. The altertoxins, although produced in very small amounts, are included because of their apparent toxicity/mutagencity. Published methods used to isolate and purify or analyze these important toxins are grouped for comparison according to similarities in extraction, isolation and analysis. Methods used for quantitative analysis are separated from those used primarily for preparation and purification. Published detection limits and recoveries are compared. Analytical needs and prospects are discussed.
本文列出了链格孢属产生的40种次生代谢产物的一些物理和化学性质，并附有文献参考。深入综述了这些潜在毒素几类中的三类的分析方法，因为这些类别中的化合物由许多链格孢属大量产生和/或显然具有剧毒或致突变性。就产生量和毒性而言，细交链孢菌酮酸、交链孢酚和交链孢酚单甲醚是主要毒素。变应原毒素尽管产生量极少，但因其明显的毒性/致突变性而被纳入。根据提取、分离和分析的相似性，将用于分离、纯化或分析这些重要毒素的已发表方法分组进行比较。用于定量分析的方法与主要用于制备和纯化的方法分开。比较了已发表的检测限和回收率。讨论了分析需求和前景。
