Sulaiman Sarah, Marciani Luca
Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham NG7 2UH, UK.
Pharmaceutics. 2019 Mar 27;11(4):146. doi: 10.3390/pharmaceutics11040146.
Oral solid drug formulation is the most common route for administration and it is vital to increase knowledge of the gastrointestinal physiological environment to understand dissolution and absorption processes and to develop reliable biorelevant in vitro tools. In particular, colon targeted drug formulations have raised the attention of pharmaceutical scientists because of the great potential of colonic drug delivery. However, the distal bowel is still a relatively understudied part of the gastrointestinal tract. Recently, magnetic resonance imaging (MRI) has been gaining an emerging role in studying the colon. This article provides a comprehensive; contemporary review of the literature on luminal MRI of the colonic environment of the last 15 years with specific focus on colon physiological dimensions; motility; chyme and fluids; transit and luminal flow. The work reviewed provides novel physiological insight that will have a profound impact on our understanding of the colonic environment for drug delivery and absorption and will ultimately help to raise the in vitro/in vivo relevance of computer simulations and bench models.
口服固体药物制剂是最常见的给药途径，增加对胃肠道生理环境的了解对于理解药物溶解和吸收过程以及开发可靠的体外生物相关性工具至关重要。特别是，结肠靶向药物制剂因其在结肠给药方面的巨大潜力而引起了药物科学家的关注。然而，远端肠道仍是胃肠道中研究相对较少的部分。最近，磁共振成像（MRI）在研究结肠方面发挥着越来越重要的作用。本文对过去15年有关结肠环境腔内MRI的文献进行了全面、当代的综述，特别关注结肠的生理尺寸、运动性、食糜和液体、转运和腔内流动。所综述的工作提供了新颖的生理学见解，这将对我们理解药物递送和吸收的结肠环境产生深远影响，并最终有助于提高计算机模拟和实验台模型的体外/体内相关性。
