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视网膜色素变性中神经丝蛋白抗体

Antibodies to neurofilament protein in retinitis pigmentosa.

作者信息

Galbraith G M, Emerson D, Fudenberg H H, Gibbs C J, Gajdusek D C

出版信息

J Clin Invest. 1986 Oct;78(4):865-9. doi: 10.1172/JCI112672.

DOI:10.1172/JCI112672
PMID:3093532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC423702/
Abstract

Antibodies reactive with heterologous neural tissue were detected by indirect immunofluorescence microscopy in the sera of 17 of 34 patients with retinitis pigmentosa, one of 30 normal control sera, and a variable percentage of sera derived from subjects with diverse ocular and neurological diseases. These antibodies were also found both in disease-free first degree relatives and in spouses of patients with retinitis pigmentosa. Analytical sodium dodecyl sulfate-polyacrylamide gel electrophoresis of human spinal cord components followed by immunoblots with sera under study revealed that the serum antibody was specific for the high molecular weight protein subunit of neurofilaments. No correlation was found between the presence of these antibodies and other immunological and clinical parameters in retinitis pigmentosa. These findings suggest that release of piled-up neurofilaments from damaged neurones in retinitis pigmentosa triggers B lymphocytes autoreactive to neurofilament antigens.

摘要

通过间接免疫荧光显微镜检查，在34例色素性视网膜炎患者中的17例血清、30例正常对照血清中的1例以及来自患有各种眼部和神经疾病受试者的不同比例血清中，检测到了与异源神经组织发生反应的抗体。在色素性视网膜炎患者的无病一级亲属和配偶中也发现了这些抗体。对人脊髓成分进行十二烷基硫酸钠-聚丙烯酰胺凝胶电泳分析，随后用研究中的血清进行免疫印迹，结果显示血清抗体对神经丝的高分子量蛋白亚基具有特异性。在色素性视网膜炎中，未发现这些抗体的存在与其他免疫和临床参数之间存在相关性。这些发现表明，色素性视网膜炎中受损神经元堆积的神经丝释放，触发了对神经丝抗原具有自身反应性的B淋巴细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b77a/423702/742a32bd310a/jcinvest00109-0020-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b77a/423702/bf4e602092b2/jcinvest00109-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b77a/423702/35d60ef6fc7f/jcinvest00109-0019-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b77a/423702/559a9fe828dd/jcinvest00109-0019-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b77a/423702/48c039579308/jcinvest00109-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b77a/423702/742a32bd310a/jcinvest00109-0020-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b77a/423702/bf4e602092b2/jcinvest00109-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b77a/423702/35d60ef6fc7f/jcinvest00109-0019-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b77a/423702/559a9fe828dd/jcinvest00109-0019-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b77a/423702/48c039579308/jcinvest00109-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b77a/423702/742a32bd310a/jcinvest00109-0020-b.jpg

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FURTHER STUDIES OF BODIAN'S TECHNIQUE; WITH SPECIAL EMPHASIS ON THE IMPREGNATING AND REDUCING SOLUTIONS.博迪安技术的进一步研究；特别着重于浸染液和还原液
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Population genetic studies of retinitis pigmentosa.视网膜色素变性的群体遗传学研究。
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Antibody to intermediate filaments of the cytoskeleton.抗细胞骨架中间丝抗体。
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Analysis of IgG antibody patterns against retinal antigens and antibodies to alpha-crystallin, GFAP, and alpha-enolase in sera of patients with "wet" age-related macular degeneration.“湿性”年龄相关性黄斑变性患者血清中针对视网膜抗原的IgG抗体模式以及抗α-晶状体蛋白、GFAP和α-烯醇化酶抗体的分析。
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Retinopathies associated with antiretinal antibodies.与抗视网膜抗体相关的视网膜病变。
Clin Diagn Lab Immunol. 2001 Sep;8(5):853-8. doi: 10.1128/CDLI.8.5.853-858.2001.
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Investigations of antiretinal antibodies in pigmentary retinopathy and other retinal degenerations.色素性视网膜病变及其他视网膜变性中抗视网膜抗体的研究。
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Antineurofilament and antiretinal antibodies in AIDS patients with cytomegalovirus retinitis.患有巨细胞病毒性视网膜炎的艾滋病患者中的抗神经丝抗体和抗视网膜抗体。
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Antibodies to different isoforms of the heavy neurofilament protein (NF-H) in normal aging and Alzheimer's disease.正常衰老和阿尔茨海默病中针对重链神经丝蛋白（NF-H）不同亚型的抗体
Mol Neurobiol. 1994 Aug-Dec;9(1-3):83-91. doi: 10.1007/BF02816107.
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Heterogeneity of Alzheimer's disease. An interpretive review.阿尔茨海默病的异质性。一项解释性综述。
Mol Neurobiol. 1994 Aug-Dec;9(1-3):55-71. doi: 10.1007/BF02816105.
10
A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy.一种光感受器钙结合蛋白可被从癌症相关性视网膜病变患者获得的自身抗体识别。
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Autoantibodies against axonal neurofilaments in patients with Kuru and Creutzfeldt-Jakob disease.库鲁病和克雅氏病患者中针对轴突神经丝的自身抗体。
Science. 1980 Oct 10;210(4466):190-3. doi: 10.1126/science.6997994.
5
Immune reactivity to different retinal antigens in patients suffering from retinitis pigmentosa.色素性视网膜炎患者对不同视网膜抗原的免疫反应性。
Invest Ophthalmol Vis Sci. 1980 Jul;19(7):743-50.
6
Heterogeneic autoantibody against neurofilament protein in the sera of animals with experimental kuru and Creutzfeldt-Jakob disease and natural scrapie infection.患有实验性库鲁病、克雅氏病以及自然感染羊瘙痒病的动物血清中针对神经丝蛋白的异种自身抗体。
Infect Immun. 1982 Oct;38(1):316-24. doi: 10.1128/iai.38.1.316-324.1982.
7
Simultaneous separation and purification of neurofilament and glial filament proteins from brain.从大脑中同时分离和纯化神经丝蛋白和神经胶质丝蛋白。
J Neurochem. 1982 Jan;38(1):142-50. doi: 10.1111/j.1471-4159.1982.tb10865.x.
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Progressive retinal degeneration in scrapie-infected hamsters: a light and electron microscopic analysis.瘙痒病感染仓鼠的进行性视网膜变性：光镜和电镜分析
Lab Invest. 1981 Jan;44(1):34-42.
9
SDS-PAGE strongly overestimates the molecular masses of the neurofilament proteins.十二烷基硫酸钠-聚丙烯酰胺凝胶电泳（SDS-PAGE）严重高估了神经丝蛋白的分子量。
FEBS Lett. 1984 May 7;170(1):81-4. doi: 10.1016/0014-5793(84)81373-3.
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One subset of patients with retinitis pigmentosa has immunologic defects.视网膜色素变性患者的一个亚组存在免疫缺陷。
Clin Immunol Immunopathol. 1984 May;31(2):254-60. doi: 10.1016/0090-1229(84)90245-9.