Galbraith G M, Fudenberg H H
Clin Immunol Immunopathol. 1984 May;31(2):254-60. doi: 10.1016/0090-1229(84)90245-9.
Immunological evaluation of 20 patients with retinitis pigmentosa (RP) revealed significantly diminished circulating T-lymphocyte numbers and function and a high frequency of serum antibodies to human IgG in comparison with a healthy matched control population. However, these differences were due to severely abnormal results found in one subpopulation within the total patient group; this dichotomy was unrelated to the mode of inheritance or clinical severity of RP in individual patients. Thus, RP appears to be a syndrome rather than a disease and includes a form characterized by defective immunity. Whether this is involved in the pathogenesis of the retinal degenerative process is conjectural.
对20例视网膜色素变性（RP）患者的免疫学评估显示，与健康对照人群相比，循环T淋巴细胞数量和功能显著降低，且血清抗人IgG抗体频率较高。然而，这些差异是由于在整个患者组中的一个亚组中发现了严重异常的结果；这种二分法与个体患者的RP遗传模式或临床严重程度无关。因此，RP似乎是一种综合征而非疾病，并且包括一种以免疫缺陷为特征的形式。这是否参与视网膜退行性变过程的发病机制尚属推测。
