Larson H E, Price A B, Borriello S P
J Infect Dis. 1980 Sep;142(3):408-13. doi: 10.1093/infdis/142.3.408.
Hamsters can survive a course of clindamycin if they are held in a protected environment. Inoculation of Clostridium difficile regularly results in fatal enterocecitis in such animals but is without effect in untreated animals. These findings suggest that in the development of enterocecitis, clindamycin treatment and infection with C. difficile are separate events, and they imply that hamsters usually acquire C. difficile from environmental sources. Environments appear to differ in the risk of exposure to C. difficile, high-, medium-, and low-risk areas being recognizable. Once introduced, C. difficile may spread from animal to animal. Parallel with the incidence and epidemiology of human antibiotic-associated pseudomembranous colitis are discussed.
如果将仓鼠置于受保护的环境中，它们可以在接受克林霉素疗程后存活下来。定期接种艰难梭菌通常会导致此类动物发生致命性小肠结肠炎，但对未治疗的动物没有影响。这些发现表明，在小肠结肠炎的发展过程中，克林霉素治疗和艰难梭菌感染是两个独立的事件，这意味着仓鼠通常从环境来源感染艰难梭菌。不同环境中接触艰难梭菌的风险似乎有所不同，可以识别出高、中、低风险区域。一旦引入，艰难梭菌可能会在动物之间传播。文中还讨论了与人类抗生素相关性假膜性结肠炎的发病率和流行病学情况。
