Lowe Kimberly, Kubra Khadija Tul, He Ze Yang, Carey Katherine
Sr Care Pharm. 2019 Apr 1;34(4):253-257. doi: 10.4140/TCP.n.2019.253.
For the past 15 years, cardiovascular disease (CVD) has been the leading cause of death for both men and women in the United States and worldwide. With an aging population, there has been increasing use of statin therapy to reduce the risk of CVD. However, statin-associated muscle symptoms (SAMS) remain an obstacle to this treatment, leading to discontinuation and nonadherence to statin therapy. Signs and symptoms of SAMS include muscle pain, tenderness, and increased serum creatine kinase. Despite the idiopathic pathophysiology of SAMS, some studies have shown an association between vitamin D deficiency and SAMS; the use of vitamin D supplements can lead to relief of these symptoms. The purpose of this review was to critique evidence for the association between low serum vitamin D and SAMS and the use of vitamin D supplementation for treatment.
在过去15年里，心血管疾病（CVD）一直是美国和全球男性和女性的主要死因。随着人口老龄化，他汀类药物疗法用于降低心血管疾病风险的情况越来越多。然而，他汀类药物相关肌肉症状（SAMS）仍然是这种治疗的一个障碍，导致停药和不坚持他汀类药物治疗。SAMS的体征和症状包括肌肉疼痛、压痛和血清肌酸激酶升高。尽管SAMS的病理生理机制不明，但一些研究表明维生素D缺乏与SAMS之间存在关联；使用维生素D补充剂可缓解这些症状。本综述的目的是对低血清维生素D与SAMS之间的关联以及使用维生素D补充剂进行治疗的证据进行评判。
