Medical School of Marília, UNIMAR, Marília, São Paulo, Brazil; Food Technology School, Marília, São Paulo, Brazil.
Medical School of Marília, UNIMAR, Marília, São Paulo, Brazil.
Complement Ther Med. 2019 Apr;43:148-153. doi: 10.1016/j.ctim.2019.01.015. Epub 2019 Jan 19.
this review aimed to investigate the effects of green tea polyphenols (GTP) in Ulcerative colitis and Crohn´s Disease.
The databases used were MEDLINE-and EMBASE (October 2009 to September 2018). Studies that reported the use of green tea and its effects on IBD were included.
Ten articles were included in this review.
GTP play a role in reducing TNF-α, Interleukin 1β (IL-1β), IL-6, IL-8, and 17; downregulate cyclooxygenase-mediated I kappa B kinase and transcription of NFκB. They regulate the pathways mediated by the Nuclear erythroid 2-related factor 2, mitogen-activated protein kinases, and signal transducer and the activator of transcription 1/3, and also minimize the lipid peroxidation. Furthermore, GTP can stimulate antioxidant enzymes. These actions reduce inflammatory and oxidant patterns in IBD resulting in improvement of the disease scores.
We suggest that professionals and researchers take into account the use of GTP in further researches and in clinical practice in order to verify the real effects in humans.
本综述旨在探讨绿茶多酚（GTP）对溃疡性结肠炎和克罗恩病的作用。
使用的数据库为 MEDLINE 和 EMBASE（2009 年 10 月至 2018 年 9 月）。纳入报告绿茶使用及其对 IBD 影响的研究。
本综述纳入了 10 篇文章。
GTP 可降低 TNF-α、白细胞介素 1β（IL-1β）、IL-6、IL-8 和 17；下调环氧化酶介导的 IκB 激酶和 NFκB 转录。它们调节核红细胞 2 相关因子 2、丝裂原活化蛋白激酶和信号转导和转录激活因子 1/3 介导的途径，并最大限度地减少脂质过氧化。此外，GTP 可刺激抗氧化酶。这些作用可减轻 IBD 中的炎症和氧化模式，从而改善疾病评分。
我们建议专业人员和研究人员在进一步的研究和临床实践中考虑使用 GTP，以验证其对人类的真实效果。
