Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran; Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Faculty of Health, Arak University of Medical Sciences, Arak, Iran.
Complement Ther Med. 2019 Apr;43:20-27. doi: 10.1016/j.ctim.2018.12.022. Epub 2019 Jan 2.
Diabetes mellitus is one of the most common endocrine disorders in the world. This systematic review was conducted with focus on the current knowledge on the effect of royal jelly on metabolic variables in diabetes mellitus. PubMed, Scopus, Embase, ProQuest and Google Scholar databases were searched from inception until June 2018. All clinical trials and animal studies that evaluated the effects of royal jelly on diabetes mellitus, and were published in English-language journals were eligible. Studies that provided insufficient outcomes were excluded. Out of 522 articles found in the search, only twelve articles were eligible for analysis. Seven studies showed a significant reduction in FBS, and one reported HbA1c decrease following royal jelly supplementation. Although royal jelly supplementation resulted in significant reductions in HOM A-I R in three studies, the findings on insulin levels were controversial. In addition, royal jelly substantially improved serum levels of triglycerides, cholesterol, HDL, LDL, VLDL and Apo-A1 in diabetes mellitus. In addition, royal jelly resulted in a decrease oxidative stress indicators and increase antioxidant enzymes levels. In conclusion, royal jelly could improve glycemic status, lipid profiles and oxidative stress in diabetes mellitus. However, exploring the underlying mechanisms warrants further studies.
糖尿病是世界上最常见的内分泌疾病之一。本系统评价主要关注蜂王浆对糖尿病代谢变量影响的现有知识。从创建到 2018 年 6 月，我们在 PubMed、Scopus、Embase、ProQuest 和 Google Scholar 数据库中进行了检索。所有评估蜂王浆对糖尿病影响的临床试验和动物研究，只要发表在英文期刊上，均符合入选标准。对提供的结果不充分的研究进行了排除。在搜索中发现的 522 篇文章中，只有 12 篇文章符合分析要求。有 7 项研究表明蜂王浆补充剂可显著降低空腹血糖，1 项研究表明蜂王浆补充剂可降低 HbA1c。尽管有 3 项研究表明蜂王浆补充剂可显著降低 HOMA-IR，但胰岛素水平的研究结果存在争议。此外，蜂王浆可显著改善糖尿病患者的甘油三酯、胆固醇、HDL、LDL、VLDL 和 Apo-A1 血清水平。此外，蜂王浆可降低氧化应激标志物水平并增加抗氧化酶水平。总之，蜂王浆可以改善糖尿病患者的血糖状况、血脂谱和氧化应激。然而，探索潜在的机制需要进一步的研究。
