Irle E, Markowitsch H J
J Hirnforsch. 1986;27(3):343-67.
Afferent connections to the substantia innominata/nucleus basalis complex of monkeys and cats were traced by using the method of retrograde transport of horseradish peroxidase (HRP). Altogether ten injections of HRP were performed in four monkeys (Saimiri sciureus, Callithrix jacchus, Galago senegalensis) and in four cats, with either vertical or oblique needle approaches. The entire brains excluding the olfactory bulbs and the cerebellum were then screened for labeled neurons. In both monkey and cat brains, many retrogradely labeled neurons could be detected in the amygdala, hypothalamus, midline thalamus, zona incerta, and the fields of Forel. Further but weaker labeling occurred in the medial septal nucleus, diagonal band of Broca, olfactory tubercle, paraventricular, anterior, mediodorsal, and central lateral thalamic nuclei, lateral habenula, ventral tegmental area of Tsai, interpeduncular nucleus, parabrachial, raphe, dorsal tegmental nucleus and the locus caeruleus. Cortically, prefrontal, insular, entorhinal, prepiriform, and periamygdaloid areas of both species showed considerable labeling as well as the whole temporal lobe of the monkeys used. The perirhinal and basal temporal cortex of all cats showed moderate labeling. In both monkeys and cats, extremely scarce labeling occurred within the cingulate, retrosplenial, and subicular cortex. From an anatomical point of view, the manifold connections of the substantia innominata/basal nucleus of Meynert found in this study underscore the participation of these nuclear groups in motivational, emotional, and cognitive (e.g. mnemonic) functions. Considering the widespread cortical efferents of this complex, it is suggested that the substantia innominata/nucleus basalis of Meynert serves the transmission of information arising within the limbic system to the whole neocortex.
采用辣根过氧化物酶（HRP）逆行运输法追踪了猴和猫无名质/基底核复合体的传入连接。在4只猴（松鼠猴、狨猴、塞内加尔婴猴）和4只猫身上共进行了10次HRP注射，进针途径为垂直或倾斜进针。然后对除嗅球和小脑外的整个大脑进行标记神经元筛查。在猴和猫的大脑中，均可在杏仁核、下丘脑、中线丘脑、未定带和Forel区检测到许多逆行标记神经元。在内侧隔核、Broca斜角带、嗅结节、室旁核、前核、背内侧核、中央外侧丘脑核、外侧缰核、蔡氏腹侧被盖区、脚间核、臂旁核、中缝核、背侧被盖核和蓝斑中，标记较弱。在皮质方面，两种动物的前额叶、岛叶、内嗅区、梨状前区和杏仁周区均显示出大量标记，所用猴的整个颞叶也有大量标记。所有猫的梨周皮质和颞叶基底皮质显示中度标记。在猴和猫中，扣带回、压后皮质和海马下托皮质内的标记极少。从解剖学角度来看，本研究中发现的无名质/Meynert基底核的多种连接强调了这些核团参与动机、情感和认知（如记忆）功能。考虑到该复合体广泛的皮质传出纤维，提示无名质/Meynert基底核负责将边缘系统内产生的信息传递至整个新皮质。
