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越来越多的证据表明透明质酸在皮肤生物学中起着重要作用。

Emerging evidence for the essential role of hyaluronan in cutaneous biology.

机构信息

Department of Dermatology, Ehime University Graduate School of Medicine, Toon, Japan.

Department of Dermatology, Ehime University Graduate School of Medicine, Toon, Japan.

出版信息

J Dermatol Sci. 2019 Apr;94(1):190-195. doi: 10.1016/j.jdermsci.2019.01.009. Epub 2019 Mar 19.

DOI:10.1016/j.jdermsci.2019.01.009
PMID:30935779
Abstract

Hyaluronan (HA), a linear non-sulfated glycosaminoglycan, participates in a variety of biological processes in the skin, such as cell-matrix interactions and activation of chemokines/cytokines, enzymes, and growth factors. In these activation events, HA acts as a damage-associated molecular pattern (DAMP). This review discusses the progress in functional research on HA, and its associated factors, in several aspects of cutaneous biology; e.g., immunity and wound repair.

摘要

透明质酸（HA）是一种线性非硫酸化糖胺聚糖，参与皮肤中的多种生物学过程，如细胞-基质相互作用和趋化因子/细胞因子、酶和生长因子的激活。在这些激活事件中，HA 作为损伤相关分子模式（DAMP）发挥作用。本综述讨论了 HA 及其相关因素在皮肤生物学的几个方面的功能研究进展，例如免疫和伤口修复。

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