Jariwala Ripal, Zeitler Kristen, Riddle Nicole D, Sriaroon Chakrapol
Department of Pharmacy, Tampa General Hospital, Tampa, Florida, USA.
USF Pathology, Ruffolo, Hooper and Associates, Tampa, Florida, USA.
BMJ Case Rep. 2019 Mar 31;12(3):e228150. doi: 10.1136/bcr-2018-228150.
The use of immunosuppressing agents can act as a catalyst for viral reactivation, promoting systemic infection with organ involvement. Current literature remains sparse on this topic but does provide individual case reports involving single viruses. We present the case of an immunocompromised patient with skin lesions, pancreatitis, colitis and hepatitis. Work-up revealed varicella zoster virus, which likely put the patient at risk for multi-organ involvement, as well as clinical suspicion of other implicated viruses, specifically herpes simplex virus and cytomegalovirus. A high clinical index of suspicion along with biopsy guidance for viral involvement in immunocompromised patients is crucial for early diagnosis and treatment of these conditions.
免疫抑制剂的使用可成为病毒再激活的催化剂，促使病毒全身性感染并累及器官。目前关于这一主题的文献仍然稀少，但确实提供了涉及单一病毒的个别病例报告。我们报告一例免疫功能低下患者，出现皮肤病变、胰腺炎、结肠炎和肝炎。检查发现水痘带状疱疹病毒，这可能使患者面临多器官受累的风险，同时临床上怀疑还有其他相关病毒，特别是单纯疱疹病毒和巨细胞病毒。对于免疫功能低下患者，高度的临床怀疑指数以及针对病毒感染的活检指导对于这些疾病的早期诊断和治疗至关重要。
