内皮细胞表现为软骨破骨细胞。
Endothelial cells revealed as chondroclasts.
作者信息
Iqbal Jameel, Zaidi Mone
机构信息
Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Pathology, James J. Peters VA Medical Center, Bronx, NY, USA.
出版信息
Nat Cell Biol. 2019 Apr;21(4):417-419. doi: 10.1038/s41556-019-0306-5.
Abstract
Osteoclasts are known for their role in bone resorption. A study now shows that a vascular–associated osteoclast subtype at the growth plate also regulates blood vessel growth in bone and is supported by type H endothelial cells. These type H capillaries, in turn, release proteinases that promote cartilage degradation.
摘要
破骨细胞因其在骨吸收中的作用而闻名。一项研究表明，生长板处一种与血管相关的破骨细胞亚型也可调节骨内血管生长，并得到H型内皮细胞的支持。反过来，这些H型毛细血管会释放促进软骨降解的蛋白酶。
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Stem Cells Int. 2017;2017:5046953. doi: 10.1155/2017/5046953. Epub 2017 Sep 17.
2
Blood flow controls bone vascular function and osteogenesis.血流控制着骨骼的血管功能和成骨作用。
Nat Commun. 2016 Dec 6;7:13601. doi: 10.1038/ncomms13601.
3
Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals.血管衍生信号对造血和骨生成的调控。
Annu Rev Cell Dev Biol. 2016 Oct 6;32:649-675. doi: 10.1146/annurev-cellbio-111315-124936. Epub 2016 Aug 17.
4
A Tale of Two Joints: The Role of Matrix Metalloproteases in Cartilage Biology.两个关节的故事：基质金属蛋白酶在软骨生物学中的作用
Dis Markers. 2016;2016:4895050. doi: 10.1155/2016/4895050. Epub 2016 Jul 13.
5
Closing the loop on the bone-resorbing osteoclast.阻断破骨细胞的骨吸收作用。
Nat Med. 2016 May 5;22(5):460-1. doi: 10.1038/nm.4104.
6
Angiogenic-osteogenic coupling: the endothelial perspective.血管生成-成骨耦合：内皮细胞视角
Bonekey Rep. 2014 Oct 15;3:578. doi: 10.1038/bonekey.2014.73. eCollection 2014.
7
Unraveling metalloproteinase function in skeletal biology and disease using genetically altered mice.利用基因工程小鼠解析金属蛋白酶在骨骼生物学和疾病中的功能。
Biochim Biophys Acta. 2010 Jan;1803(1):121-32. doi: 10.1016/j.bbamcr.2009.07.002. Epub 2009 Jul 17.
8
Skeletal remodeling in health and disease.健康与疾病中的骨骼重塑
Nat Med. 2007 Jul;13(7):791-801. doi: 10.1038/nm1593.
9
Molecular regulation of mechanotransduction.机械转导的分子调控
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