快速进展性骨关节炎与夏科关节病的重叠特征。
Overlapping features of rapidly progressive osteoarthrosis and Charcot arthropathy.
作者信息
Sono Takashi, Meyers Carolyn A, Miller Daniel, Ding Catherine, McCarthy Edward F, James Aaron W
机构信息
Department of Pathology, Johns Hopkins University, Ross Research Building, Room 524A, 720 Rutland Avenue, Baltimore, MD, 21205, United States.
Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
出版信息
J Orthop. 2019 Mar 12;16(3):260-264. doi: 10.1016/j.jor.2019.02.015. eCollection 2019 May-Jun.
Nerve growth factor (NGF) is the primary neurotrophin in the skeleton and a central mediator of skeletal pain. Recent trials of anti-NGF neutralizing antibodies have resulted in infrequent but well-described incidence of rapidly progressive osteoarthrosis (RPOA). Neuropathy, whether from syphilis or diabetes, is also associated with severe joint destruction, known as neuroarthropathy or Charcot joint. These commonalities of severe joint destruction with either loss of a neurotrophin (anti-NGF) or a deficit of functional skeletal innervation led us to examine our institutional case files for potential radio-pathologic overlap between RPOA and Charcot joint.
神经生长因子（NGF）是骨骼中的主要神经营养因子，也是骨骼疼痛的核心介质。最近对抗NGF中和抗体的试验导致了快速进展性骨关节炎（RPOA）发生率虽低但描述详尽。无论是梅毒还是糖尿病引起的神经病变，也都与严重的关节破坏有关，即神经关节病或夏科关节。这些因神经营养因子缺失（抗NGF）或功能性骨骼神经支配不足而导致严重关节破坏的共性，促使我们查阅本机构的病例档案，以寻找RPOA与夏科关节之间潜在的放射病理学重叠情况。
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