Brown R C, Chalmers D M, Rowe V L, Kelleher J, Littlewood J M, Losowsky M S
J Clin Pathol. 1982 May;35(5):547-9. doi: 10.1136/jcp.35.5.547.
We have measured serum immunoreactive trypsin (IRT) and serum pancreatic isoamylase (PIA) activities using commercially available kits in 37 cystic fibrosis (CF) patients and 46 hospital controls of similar age range. Immunoreactive trypsin was more often abnormal than PIA (26/37 v 18/37 abnormal respectively); IRT will be particularly useful as an additional diagnostic test in older children, in whom interpretation of the sweat test may be difficult, as 14/15 CF patients aged over 10 years had abnormal IRT results. Less than half of our patients who were aged between one and nine years had abnormal IRT activity, limiting the value of the test, though a low activity would still support the diagnosis of CF. Comparison with faecal fat estimations in 31 patients suggests that neither IRT nor PIA can be used as a non-invasive test of pancreatic function in order to identify those few CF patients who do not require pancreatic enzyme supplements.
我们使用市售试剂盒，对37例囊性纤维化（CF）患者和46例年龄范围相似的医院对照者测定了血清免疫反应性胰蛋白酶（IRT）和血清胰腺异淀粉酶（PIA）活性。免疫反应性胰蛋白酶异常的情况比PIA更常见（分别为26/37和18/37异常）；IRT作为一项额外的诊断测试，在大龄儿童中特别有用，因为对他们来说，汗液试验的解读可能困难，15例10岁以上CF患者中有14例IRT结果异常。1至9岁的患者中，IRT活性异常的不到一半，这限制了该测试的价值，不过低活性仍可支持CF的诊断。对31例患者粪便脂肪估计值的比较表明，IRT和PIA均不能用作胰腺功能的非侵入性测试，以识别那些不需要补充胰酶的少数CF患者。
