Haygarth Madeleine, Zaw Kyi Kyi, Yachmenikova Victoria, Pokorny Adrian M J, Kwong Kin Keung, Heraganahally Subash S
Department of Respiratory Medicine, Royal Darwin Hospital, Darwin, NT, Australia.
Department of Anatomical Pathology, Royal Darwin Hospital, Darwin, NT, Australia.
Respir Med Case Rep. 2019 Mar 4;26:326-327. doi: 10.1016/j.rmcr.2019.03.003. eCollection 2019.
Diffuse pulmonary metastasis secondary to primary peritoneal malignant mesothelioma is rarely reported in the literature. In this report we describe a 59-year-old Caucasian women with no known previous asbestos exposure presenting with bilateral diffuse pulmonary opacities in association with primary malignant peritoneal mesothelioma. The diagnosis was confirmed by ultrasound guided abdominal and bronchoscopy, -bronchial lung biopsy. The biopsy demonstrated positive staining with AE1/3, CK7, CK5/6, WT1, calretinin and D2 40. The cells were negative for BerEP4, PAX8, CA125, ER, CD34, ERG, P63, P40, Melan A, Gata3 and mammaglobin. The morphology and immunohistochemical profile supported a diagnosis of epithelioid malignant mesothelioma.
原发性腹膜恶性间皮瘤继发的弥漫性肺转移在文献中鲜有报道。在本报告中，我们描述了一名59岁的白种女性，既往无已知石棉接触史，因原发性恶性腹膜间皮瘤出现双侧弥漫性肺混浊。通过超声引导下腹部活检及支气管镜下肺活检确诊。活检显示AE1/3、CK7、CK5/6、WT1、钙视网膜蛋白和D2-40染色呈阳性。细胞对BerEP4、PAX8、CA125、雌激素受体（ER）、CD34、ERG、P63、P40、黑素A、Gata3和乳珠蛋白呈阴性。形态学和免疫组化特征支持上皮样恶性间皮瘤的诊断。
