Suzuki Satoshi, Nakatani Shimpei, Sotomi Yohei, Shiojima Ichiro, Sakata Yasushi, Higuchi Yoshiharu
Department of Cardiology, Osaka Police Hospital, Osaka, Japan.
Department of Medicine II, Kansai Medical University, Hirakata, Japan.
J Int Med Res. 2020 Jan;48(1):300060519837445. doi: 10.1177/0300060519837445. Epub 2019 Apr 2.
The drug-coated balloon (DCB) angioplasty is considered a standard therapeutic option for in-stent restenosis. In the present case, we observed high-intensity spots on optical coherence tomography (OCT) and bright spots on coronary angioplasty (CAS) immediately after DCB angioplasty. The superficial high-intensity area on OCT presumably corresponded with the bright spots on CAS. The high-intensity superficial regions were thought to represent an iopromide/paclitaxel mixture. The present serial observation demonstrated that the eluted drugs remained for at least 2 months but disappeared within 6 months. At the site where we observed the drugs, neointimal growth was successfully inhibited and stabilized at the 6-month follow-up. The association of eluted drugs after DCB angioplasty with consequent neointimal growth is of scientific interest. Further prospective imaging studies with a large sample size are warranted to clarify this association.
药物涂层球囊血管成形术被认为是治疗支架内再狭窄的标准方法。在本病例中，我们在药物涂层球囊血管成形术后立即在光学相干断层扫描（OCT）上观察到高强度斑点，在冠状动脉血管造影（CAS）上观察到亮点。OCT上的浅表高强度区域可能与CAS上的亮点相对应。高强度浅表区域被认为代表了碘普罗胺/紫杉醇混合物。本系列观察表明，洗脱药物至少保留2个月，但在6个月内消失。在我们观察到药物的部位，新生内膜生长在6个月随访时得到成功抑制并稳定。药物涂层球囊血管成形术后洗脱药物与随后新生内膜生长之间的关联具有科学研究价值。有必要进行进一步的大样本前瞻性影像学研究以阐明这种关联。
