Yeom Jung Sook, Jo Jae-Young, Park Ji Sook, Kim Young-Soo, Chung Ju-Young, Han Tae-Hee, Seo Ji-Hyun, Park Eun Sil, Lim Jae-Young, Woo Hyang-Ok, Youn Hee-Shang, Park Chan-Hoo
Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
Neuropediatrics. 2019 Aug;50(4):228-234. doi: 10.1055/s-0038-1677516. Epub 2019 Apr 2.
Recent reports have suggested an association between rotavirus infection and a distinctive pattern of white matter injury (WMI) in neonates with seizures; however, the connection between the two is not fully understood. To evaluate the underlying mechanism, we profiled and compared eight cytokines (IL [interleukin]-1, IL-6, IL-8, IL-10, IFN- [interferon- ], MCP-1 [monocyte chemoattractant protein-1], MIP-1 [macrophage inflammatory protein-1], and TNF- [tumor necrosis factor-]) in the cerebrospinal fluid (CSF) of 33 neonates with seizures who had no other well-known causes of seizures and 13 control patients (rotavirus-induced gastroenteritis but without seizures). Among the 33 neonates with seizures, 9 showed WMI and all were infected with rotavirus (R + W + ). Among the 24 patients without WMI, 11 were infected with rotavirus (R + W - ) and 13 were not (R - W - ).Only MCP-1 and MIP-1 were different between the groups. MCP-1 was increased in R+ W+ compared with R + W- ( < 0.01), R - W- ( < 0.01), and control ( = 0.03) patients. MIP-1 was decreased in R + W+ compared with R - W- ( < 0.01) and control ( < 0.01), but not R + W- ( = 0.23) patients. MCP-1 and MIP-1 are C-C chemokines that recruit immune cells to the site of inflammation. Our pilot study suggests MCP-1-mediated monocyte recruitment may be linked with this complication caused by rotavirus.
近期报告显示，轮状病毒感染与新生儿惊厥时出现的一种独特的白质损伤（WMI）模式之间存在关联；然而，两者之间的联系尚未完全明确。为评估潜在机制，我们对33例无其他已知惊厥病因的惊厥新生儿及13例对照患者（轮状病毒感染所致肠胃炎但无惊厥）的脑脊液（CSF）中的8种细胞因子（白细胞介素（IL）-1、IL-6、IL-8、IL-10、干扰素（IFN）-γ、单核细胞趋化蛋白-1（MCP-1）、巨噬细胞炎性蛋白-1（MIP-1）和肿瘤坏死因子（TNF）-α）进行了分析和比较。在33例惊厥新生儿中，9例出现WMI且均感染了轮状病毒（R+W+）。在24例无WMI的患者中，11例感染了轮状病毒（R+W-），13例未感染（R-W-）。仅MCP-1和MIP-1在各组之间存在差异。与R+W-组（P<0.01）、R-W-组（P<0.01）和对照组（P=0.03）相比，R+W+组的MCP-1升高。与R-W-组（P<0.01）和对照组（P<0.01）相比，R+W+组的MIP-1降低，但与R+W-组（P=0.23）相比无差异。MCP-1和MIP-1是C-C趋化因子，可将免疫细胞募集到炎症部位。我们的初步研究表明，MCP-1介导的单核细胞募集可能与轮状病毒引起的这种并发症有关。
