Department of Cardiology, Da Qing First Hospital, Daqing City, China.
Center of Endocrinology and Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Diabetes Metab Res Rev. 2019 Sep;35(6):e3163. doi: 10.1002/dmrr.3163. Epub 2019 Apr 25.
Limited information is available on the long-term risk of cardiovascular disease (CVD) associated with hypertriglyceridaemia (HTG) in the Chinese population. We estimated this risk over a 23-year period in participants recruited from among those included in the Da Qing Diabetes Study.
A total of 833 Chinese adults including 379 with normal glucose levels and 454 with hyperglycaemia were identified by their oral glucose tolerance in 1986 in Da Qing, China. CVD outcomes were monitored until 2009. Thirty-four percent (280/833) of the participants had HTG, which was defined as a fasting plasma triglyceride (TG) level ≥ 1.7 mmol/L, at the baseline time point.
Over the 23-yearfollow-up period, 149 subjects in the HTG group and 190 subjects in the non-HTG group (NTG group) experienced their first CVD event, including fatal or nonfatal myocardial infarction (MI) and stroke. The age and sex-adjusted annual incidence of the first CVD event per 1000 person-years was 30.23 for the HTG group vs 18.68 for the NTG group. The corresponding rates for MI and stroke were 7.71 vs 3.89 and 19.55 vs 13.98, respectively. After adjusting for confounders, the HTG group had a 28% higher risk of the first CVD event than the NTG group. This association was significant among only the subjects with a serum cholesterol level > 5.7 mmol/L and those with diabetes or impaired glucose tolerance (IGT).
HGT predicted a substantially higher subsequent long-term risk of the first CVD event in Chinese adults, especially in those with hypercholesterolaemia and hyperglycaemia.
在中国人群中，有关与高甘油三酯血症（HTG）相关的心血管疾病（CVD）的长期风险的信息有限。我们通过在中国大庆糖尿病研究中招募的参与者来估计这一风险，为期 23 年。
1986 年，在中国大庆，通过口服葡萄糖耐量试验，从包括 379 名血糖正常和 454 名高血糖的 833 名成年人中确定了 CVD 结局。直至 2009 年，监测 CVD 结局。在基线时，34%（280/833）的参与者存在 HTG，其定义为空腹血浆甘油三酯（TG）水平≥1.7mmol/L。
在 23 年的随访期间，HTG 组有 149 例和非 HTG 组（NTG 组）有 190 例发生了首次 CVD 事件，包括致命或非致命性心肌梗死（MI）和卒中。HTG 组每 1000 人年发生首次 CVD 事件的年龄和性别校正年发生率为 30.23%，NTG 组为 18.68%。相应的 MI 和卒中发生率分别为 7.71%和 3.89%，19.55%和 13.98%。调整混杂因素后，HTG 组发生首次 CVD 事件的风险比 NTG 组高 28%。这种关联仅在血清胆固醇水平>5.7mmol/L 以及患有糖尿病或糖耐量受损（IGT）的患者中显著。
HTG 预测中国成年人首次 CVD 事件的后续长期风险显著升高，尤其是在那些伴有高胆固醇血症和高血糖的人群中。
