Li Yiwen, Cui Jing, Liu Yanfei, Chen Keji, Huang Luqi, Liu Yue
National Clinical Research Center for TCM Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
The Second Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Front Cardiovasc Med. 2021 Oct 11;8:748256. doi: 10.3389/fcvm.2021.748256. eCollection 2021.
Type 2 Diabetes mellitus (T2DM) is a major risk factor for cardiovascular diseases and increase mortality. Clinical outcomes of patients after percutaneous coronary intervention (PCI) were worse in T2DM patients than those without T2DM. New-onset diabetes after PCI (NODAP) is often observed during long-term follow-up and this further aggravates cardiovascular diseases. Several studies had focused on patients after PCI with known T2DM. Previous studies showed that impaired glucose tolerance and aging are risk factors that promote NODAP. Considering the unique characteristics of patients after PCI, we will further study relevant risk factors. We sought to investigate the potential predictors of acute coronary syndrome patients with NODAP by a multicenter retrospective cohort study. This is a multicenter retrospective cohort study including patients after PCI. Clinical medical records of these patients were collected from four hospitals in different areas in China, from 2010 to 2021. Patients' demographic information, medical history, diagnostic testing, PCI-related information, medication situation will be summarized using descriptive statistics, and correlation analysis was performed on the development of new-onset diabetes. Variation will be described and evaluated using χ test or Kreskas-Wallis test. The prediction model will be verified by a validation set. A novel diabetes prediction model for patients after PCI is established, and this study can achieve advanced intervention for the occurrence of NODAP. Owing to its retrospective nature, this study has some limitations, but it will be further studied through supplement data collection or prospective study. The study has been registered for clinical trials by the Chinese Clinical Trial Registry ().
2型糖尿病（T2DM）是心血管疾病的主要危险因素，会增加死亡率。经皮冠状动脉介入治疗（PCI）后，T2DM患者的临床结局比非T2DM患者更差。PCI术后新发糖尿病（NODAP）在长期随访中经常出现，这进一步加重了心血管疾病。此前有多项研究聚焦于已知患有T2DM的PCI术后患者。既往研究表明，糖耐量受损和衰老都是促使NODAP发生的危险因素。考虑到PCI术后患者的独特特征，我们将进一步研究相关危险因素。我们试图通过一项多中心回顾性队列研究，调查发生NODAP的急性冠脉综合征患者的潜在预测因素。这是一项纳入PCI术后患者的多中心回顾性队列研究。这些患者的临床病历收集自2010年至2021年中国不同地区的四家医院。将使用描述性统计方法总结患者的人口统计学信息、病史、诊断检查、PCI相关信息、用药情况，并对新发糖尿病的发生进行相关性分析。将使用χ检验或Kreskas-Wallis检验描述并评估差异。预测模型将通过验证集进行验证。建立了一种针对PCI术后患者的新型糖尿病预测模型，本研究能够对NODAP的发生实现早期干预。由于本研究具有回顾性，存在一定局限性，但将通过补充数据收集或前瞻性研究进一步开展研究。本研究已在中国临床试验注册中心注册临床试验（）。
