Medical Science Research Institute, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea.
Department of Biochemistry, Soonchunhyang University College of Medicine, Cheonan 34538, Korea.
Int J Mol Sci. 2019 Apr 1;20(7):1619. doi: 10.3390/ijms20071619.
Kidney disease can be either acute kidney injury (AKI) or chronic kidney disease (CKD) and it can lead to the development of functional organ failure. Mesenchymal stem cells (MSCs) are derived from a diverse range of human tissues. They are multipotent and have immunomodulatory effects to assist in the recovery from tissue injury and the inhibition of inflammation. Numerous studies have investigated the feasibility, safety, and efficacy of MSC-based therapies for kidney disease. Although the exact mechanism of MSC-based therapy remains uncertain, their therapeutic value in the treatment of a diverse range of kidney diseases has been studied in clinical trials. The use of MSCs is a promising therapeutic strategy for both acute and chronic kidney disease. The mechanism underlying the effects of MSCs on survival rate after transplantation and functional repair of damaged tissue is still ambiguous. The paracrine effects of MSCs on renal recovery, optimization of the microenvironment for cell survival, and control of inflammatory responses are thought to be related to their interaction with the damaged kidney environment. This review discusses recent experimental and clinical findings related to kidney disease, with a focus on the role of MSCs in kidney disease recovery, differentiation, and microenvironment. The therapeutic efficacy and current applications of MSC-based kidney disease therapies are also discussed.
肾脏疾病可以是急性肾损伤（AKI）或慢性肾脏病（CKD），它可能导致功能性器官衰竭。间充质干细胞（MSCs）来源于多种人类组织。它们具有多能性和免疫调节作用，有助于从组织损伤中恢复和抑制炎症。许多研究已经探讨了基于 MSC 的疗法治疗肾脏疾病的可行性、安全性和疗效。尽管基于 MSC 的治疗的确切机制尚不确定，但它们在临床试验中治疗各种肾脏疾病的治疗价值已得到研究。使用 MSC 是治疗急性和慢性肾脏病的有前途的治疗策略。MSC 对移植后生存率和损伤组织功能修复的影响的机制仍不清楚。MSC 对肾脏恢复的旁分泌作用、细胞存活的微环境优化和炎症反应的控制被认为与其与受损肾脏环境的相互作用有关。本文讨论了与肾脏疾病相关的最近的实验和临床发现，重点是 MSC 在肾脏疾病恢复、分化和微环境中的作用。还讨论了基于 MSC 的肾脏疾病治疗的治疗效果和当前应用。
