Radiotherapy Oncology Department, General Regional Hospital "F. Miulli", Acquaviva delle Fonti-Bari, Italy.
Department of Biomedical and Dental Sciences and of Morphofunctional Imaging, University of Messina, Italy.
Crit Rev Oncol Hematol. 2019 Jul;139:117-124. doi: 10.1016/j.critrevonc.2019.03.008. Epub 2019 Mar 20.
Positron Emission Tomography with Computed Tomography (PET/CT) has been proven to be useful in the definition of Radiotherapy (RT) target volume. In this regard, the present expert review summarizes existing data for pancreas, prostate, gynecological and rectum/anal cancer.
A comprehensive search of published original article was made, based on SCOPUS and PubMed database, selecting the paper that evaluated the role of PET/CT in the definition of RT volume.
FDG-PET has an important and promising role for pancreatic cancer. Choline PET/CT could be useful for identifying high-risk volumes for prostate cancer; while PSMA PET/CT is still under evaluation. FDG PET/CT in gynecological cancers has been shown to impact external-beam RT planning. The role of FDG-PET for Gross Tumor volume identification is crucial, representing a useful and powerful tool for anal and rectal cancer.
Taken together, molecular and functional imaging approaches offer a major step to individualize radiotherapeutic approach.
正电子发射断层扫描与计算机断层扫描（PET/CT）已被证明可用于确定放射治疗（RT）靶区。在这方面，本专家综述总结了目前关于胰腺、前列腺、妇科和直肠/肛门癌的相关数据。
基于 SCOPUS 和 PubMed 数据库进行了已发表的原始文章的全面检索，选择评估了 PET/CT 在 RT 体积定义中的作用的论文。
FDG-PET 对胰腺癌具有重要且有前景的作用。胆碱 PET/CT 可能有助于识别前列腺癌的高危体积；而 PSMA PET/CT 仍在评估中。FDG PET/CT 在妇科癌症中的应用已显示对体外照射 RT 计划有影响。FDG-PET 用于大体肿瘤体积识别的作用至关重要，代表了一种用于肛门和直肠癌的有用且强大的工具。
总的来说，分子和功能成像方法为个体化放射治疗方法提供了重要的一步。
