Andersen P T, Bacher T, Stentoft J
Scand J Haematol. 1986 Jul;37(1):59-62. doi: 10.1111/j.1600-0609.1986.tb01772.x.
The concentration of xanthine and hypoxanthine was measured in 8 portions of SAGM red cell concentrates during 4 wk storage. The concentration of xanthine increased from 4.2 to 35.1 mumol/l and the concentration of hypoxanthine increased from 16.8 to 165.2 mumol/l (mean values). Previous studies have demonstrated several important effects of purine bases--among these a reduced cytotoxicity of purine antimetabolites. It is concluded that further studies are necessary to investigate the clinical role of purines in stored blood products.
在4周的储存期间，对8份SAGM红细胞浓缩液中的黄嘌呤和次黄嘌呤浓度进行了测量。黄嘌呤浓度从4.2微摩尔/升增加到35.1微摩尔/升，次黄嘌呤浓度从16.8微摩尔/升增加到165.2微摩尔/升（平均值）。先前的研究已经证明了嘌呤碱基的几种重要作用——其中包括嘌呤抗代谢物的细胞毒性降低。得出的结论是，有必要进行进一步研究以调查嘌呤在储存血液制品中的临床作用。
