Zhu Xuan-Xuan, Duan Pei-Bei, Wu Chang-Zheng
Department of Nursing, the Affiliated Hospital of Nanjing University of TCM, Nanjing 210000, Jiangsu Province, China.
Department of Neurology, Lianyungang Affiliated Hospital of Nanjing University of TCM.
Zhongguo Zhen Jiu. 2019 Feb 12;39(2):149-53. doi: 10.13703/j.0255-2930.2019.02.010.
To compare the efficacy difference between thumb-tack acupuncture with surrounding needling method plus medication and medication alone for herpes zoster (HZ) of stagnated heat in liver meridian type.
According to random number table method, 60 patients with HZ of stagnated heat in liver meridian type were randomly divided into an observation group and a control group, 30 cases in each one. All the patients were treated with oral valaciclovir hydrochloride dispersible tablets (0.3 g per time, twice per day), mecobalamin tablets (0.5 mg per time, three times a day) and vitamin B (10 mg per time, three times a day) for 15 days. In addition, the patients in the observation group were treated with thumb-tack acupuncture at area 1 cm outside the herpes, with an interval of 3 cm between thumb-tack needles. The thumb-tack acupuncture was given once every 3 days, retained for 48 h, with an interval of 1 day between treatments, and totally 5 treatments were given. The index of herpetic evaluation (stopping time of herpes, scarring time, decrustation time), visual analogue scale (VAS), serum immune-related factors (IgG, IgM, IgA) and serum inflammatory factors (IL-4, IL-17, TNF-α, TGF-β1) were observed before and after treatment in the two groups.
After treatment, the stopping time of herpes, scarring time, decrustation time in the observation group were shorter than those in the control group (all <0.05). Compared before treatment, the VAS score in the two groups were reduced after treatment (both <0.05), and no significant difference was observed between the two groups (>0.05), but the difference before and after treatment in the observation group was superior to that in the control group (<0.05). Compared before treatment, the levels of serum immune-related factors IgG, IgM, IgA were increased in the two groups after treatment (all <0.05), and the levels in the observation group after treatment were higher than those in the control group (all <0.05). Compared before treatment, the levels of serum inflammatory factors IL-4, IL-17, TNF-α, TGF-β1 were reduced in the two groups after treatment (all <0.05), and the levels in the observation group after treatment were lower than those in the control group (all <0.05).
The thumb-tack acupuncture with surrounding needling method plus medication have the advantages of rapid onset and analgesic effect for HZ of stagnated heat in liver meridian type, which could also improve serum immune-related factors and reduce inflammatory reaction.
比较揿针围刺法联合药物与单纯药物治疗肝经郁热型带状疱疹（HZ）的疗效差异。
按照随机数字表法，将60例肝经郁热型HZ患者随机分为观察组和对照组，每组30例。所有患者均口服盐酸伐昔洛韦分散片（每次0.3 g，每日2次）、甲钴胺片（每次0.5 mg，每日3次）及维生素B（每次10 mg，每日3次），疗程15天。此外，观察组患者在疱疹外1 cm处行揿针围刺，揿针间距3 cm。揿针每3天1次，留针48 h，治疗间隔1天，共治疗5次。观察两组治疗前后疱疹评估指标（疱疹停止时间、结痂时间、脱痂时间）、视觉模拟评分法（VAS）、血清免疫相关因子（IgG、IgM、IgA）及血清炎症因子（IL-4、IL-17、TNF-α、TGF-β1）。
治疗后，观察组疱疹停止时间、结痂时间、脱痂时间均短于对照组（均P<0.05）。与治疗前比较，两组治疗后VAS评分均降低（均P<0.05），且两组间比较差异无统计学意义（P>0.05），但观察组治疗前后差值优于对照组（P<0.05）。与治疗前比较，两组治疗后血清免疫相关因子IgG、IgM、IgA水平均升高（均P<0.05）；且观察组治疗后水平高于对照组（均P<0.05）。与治疗前比较，两组治疗后血清炎症因子IL-4、IL-17、TNF-α、TGF-β1水平均降低（均P<0.05）；且观察组治疗后水平低于对照组（均P<0.05）。
揿针围刺法联合药物治疗肝经郁热型HZ起效快、镇痛效果好，还可改善血清免疫相关因子，减轻炎症反应。
