a Department of Microbiology , Hamadan University of Medical Sciences , Hamadan , Iran.
b Modeling of Noncommunicable Diseases Research Center, Department of Biostatistics and Epidemiology, School of Public Health , Hamadan University of Medical Sciences , Hamadan , Iran.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1181-1193. doi: 10.1080/21691401.2019.1593858.
The objective of this study was to assess the antibacterial activity of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus 544. Rifampicin-loaded solid lipid nanoparticles were prepared by a modified microemulsion/sonication method and characterized. The results showed the average size about 319.7 nm, PI about 0.20 and zeta potential about 18.4 mv, encapsulation efficacy and drug-loading were equal to 95.78 and 34.2%, respectively, with a spherical shape. Drug release lasted for 5 days. The antibacterial activity was statistically significant with p < .05 in bacterial and cell culture media compared to free Rifampicin. It can be concluded that solid lipid nanoparticles can be considered as a promising delivery system for improving the antibacterial activity of Rifampicin against Brucella abortus.
本研究旨在评估利福平负载固体脂质纳米粒对布鲁氏菌 abortus 544 的抗菌活性。采用改良的微乳液/超声法制备利福平负载固体脂质纳米粒，并对其进行了表征。结果表明，平均粒径约为 319.7nm，PI 约为 0.20，zeta 电位约为 18.4mV，包封效率和载药量分别为 95.78%和 34.2%，呈球形。药物释放可持续 5 天。与游离利福平相比，在细菌和细胞培养基中的抗菌活性具有统计学意义（p<0.05）。可以得出结论，固体脂质纳米粒可以被认为是一种有前途的递药系统，可提高利福平对布鲁氏菌 abortus 的抗菌活性。
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