Taipei Cancer Center, Taipei Medical University , Taipei , Taiwan.
Graduate Institute for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University , Taipei , Taiwan.
Endocr Res. 2019 Nov;44(4):148-152. doi: 10.1080/07435800.2019.1600536. Epub 2019 Apr 3.
: Reverse T3 (rT3; 3,3',5'-triiodo-L-thyronine) is widely regarded as an inactive naturally occurring analog of thyroid hormone. rT3 is known to bind to the thyroid hormone analog receptor on plasma membrane integrin αvβ3. This integrin is generously expressed by tumor cells and is the initiation site for the stimulation by L-thyroxine (T4) at physiological free concentrations on cancer cell proliferation. : In the present studies, we show that rT3 caused increases of proliferation of 50% to 80% (P < 0.05-0.001) of human breast cancer and glioblastoma cells. : rT3 may be a host factor supporting cancer growth.
反三碘甲状腺原氨酸（rT3；3,3',5'-三碘-L-甲状腺原氨酸）被广泛认为是甲状腺激素的一种无活性天然类似物。rT3 已知与质膜整合素 αvβ3 上的甲状腺激素类似物受体结合。这种整合素在肿瘤细胞中大量表达，是在生理游离浓度下 L-甲状腺素（T4）刺激癌细胞增殖的起始部位。
在本研究中，我们表明 rT3 导致人乳腺癌和神经胶质瘤细胞增殖增加 50%至 80%（P < 0.05-0.001）。
rT3 可能是支持癌症生长的宿主因素。
