通过检测循环抗原监测猪带绦虫-神经囊尾蚴病的治疗：病例报告
Monitoring treatment of Taenia solium- neurocysticercosis by detection of circulating antigens: a case report.
作者信息
Rodríguez-Hidalgo Richar, Carpio Arturo, Van den Enden Erwin, Benítez-Ortiz Washington
机构信息
Instituto de Investigación en Salud Pública y Zoonosis, Universidad Central del Ecuador, Quito, Ecuador.
Facultad de Medicina Veterinaria y Zootecnia, Universidad Central del Ecuador, Quito, Ecuador.
出版信息
BMC Neurol. 2019 Apr 3;19(1):52. doi: 10.1186/s12883-019-1282-x.
BACKGROUND
Parenchymal neurocysticercosis is a frequent cause of seizures in areas endemic for Taenia solium. At present there is scarce data on the evolution of the levels of circulating metacestodal antigen before, during and after treatment with anthelmintic drugs.
CASE PRESENTATION
A patient with paucisymptomatic neurocysticercosis (NCC) diagnosed by Ag-ELISA, and confirmed by MRI images, was treated with praziquantel, albendazole and dexamethasone. The level of circulating T. solium antigen was determined weekly. Circulating antigen disappeared from his blood within 14 days after the start of the treatment and correlated with the involution of the cysticerci in the brain shown by imaging. Seventeen years later, the patient has not shown any side effect nor symptoms related to the treatment or to NCC.
CONCLUSIONS
If this encouraging finding is confirmed in a larger series of patients, this technique could be used to determine parasitological cure after treatment and might complement or sometimes replace sequential MRI-imaging of the brain.
背景
在猪带绦虫流行地区，实质性神经囊尾蚴病是癫痫发作的常见原因。目前，关于驱虫药物治疗前、治疗期间和治疗后循环中囊尾蚴抗原水平变化的数据很少。
病例报告
一名经抗原酶联免疫吸附测定（Ag-ELISA）诊断并经磁共振成像（MRI）图像证实为症状轻微的神经囊尾蚴病（NCC）患者，接受了吡喹酮、阿苯达唑和地塞米松治疗。每周测定循环猪带绦虫抗原水平。治疗开始后14天内，循环抗原从其血液中消失，且与影像学显示的脑内囊尾蚴退化相关。17年后，该患者未出现任何与治疗或NCC相关的副作用或症状。
结论
如果在更多患者中证实这一令人鼓舞的发现，该技术可用于确定治疗后的寄生虫学治愈情况，并可能补充或有时替代脑部的序贯MRI成像。
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