2-硝基咪唑类米索硝唑的一种具有放射增敏特性的代谢物。 - Suppr

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超能文献

A metabolite of the 2-nitroimidazole misonidazole with radiosensitizing properties.

作者信息

Flockhart I R, Sheldon P W, Stratford I J, Watts M E

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1978 Jul;34(1):91-4. doi: 10.1080/09553007814550661.

DOI:10.1080/09553007814550661

PMID:309446

Abstract

摘要

相似文献

A metabolite of the 2-nitroimidazole misonidazole with radiosensitizing properties.2-硝基咪唑类米索硝唑的一种具有放射增敏特性的代谢物。

Int J Radiat Biol Relat Stud Phys Chem Med. 1978 Jul;34(1):91-4. doi: 10.1080/09553007814550661.

Studies on the toxicity and radiosensitizing ability of misonidazole under conditions of prolonged incubation.米索硝唑在长时间孵育条件下的毒性及放射增敏能力研究

Radiat Res. 1978 Sep;75(3):541-55.

Reduction of misonidazole and its derivatives by xanthine oxidase.

Biochem Pharmacol. 1981 Apr 15;30(8):849-53. doi: 10.1016/s0006-2952(81)80006-8.

Cytotoxic properties of hydroxylamino- and amino-misonidazole, possible metabolic products of misonidazole, in hypoxic HeLa S3 cells.米索硝唑的可能代谢产物羟氨基米索硝唑和氨基米索硝唑在缺氧的海拉S3细胞中的细胞毒性特性

Gan. 1983 Oct;74(5):693-8.

Comparative misonidazole metabolism in anaerobic bacteria and hypoxic Chinese hamster lung fibroblast (V-79-473) cells.厌氧细菌与低氧中国仓鼠肺成纤维细胞（V-79-473）中米索硝唑的代谢比较

Biochem Pharmacol. 1982 Feb 1;31(3):411-4. doi: 10.1016/0006-2952(82)90190-3.

RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions.RSU 1069，一种含有氮丙啶基团的硝基咪唑。生物还原在缺氧条件下会大大增加细胞毒性。

Biochem Pharmacol. 1986 Jan 1;35(1):105-9. doi: 10.1016/0006-2952(86)90566-6.

Metabolism and radiosensitization of 4,5-dimethylmisonidazole, a ring-substituted analog of misonidazole.米索硝唑的环取代类似物4,5-二甲基米索硝唑的代谢与放射增敏作用

Biochem Pharmacol. 1992 Mar 17;43(6):1337-44. doi: 10.1016/0006-2952(92)90511-g.

Hypoxia-enhanced reduction and covalent binding of [2-3H]misonidazole in the perfused rat liver.

Biochem Pharmacol. 1984 Apr 15;33(8):1379-81. doi: 10.1016/0006-2952(84)90199-0.

Bioreductive metabolism of AF-2[2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide] combined with 2-nitroimidazoles. Implications for use as hypoxic cell markers.AF-2[2-(2-呋喃基)-3-(5-硝基-2-呋喃基)丙烯酰胺]与2-硝基咪唑的生物还原代谢。作为缺氧细胞标记物的应用意义。

Biochem Pharmacol. 1993 Sep 14;46(6):1029-36. doi: 10.1016/0006-2952(93)90667-l.

Comparison of the fate of misonidazole (RO 07-0582) and its metabolite desmethylmisonidazole (RO 05-9963), two hypoxic cell radiosensitizers: penetration properties in tumor bearing rats.两种乏氧细胞放射增敏剂米索硝唑（RO 07-0582）及其代谢产物去甲基米索硝唑（RO 05-9963）的转归比较：在荷瘤大鼠体内的渗透特性

J Pharmacol. 1983 Jan-Mar;14(1):67-77.

引用本文的文献

A drug for improved radiosensitization in radiotherapy.一种用于改善放射治疗中放射增敏作用的药物。

Br J Cancer. 1980 Jul;42(1):153-5. doi: 10.1038/bjc.1980.213.

Pharmacokinetic and tumour-penetration properties of the hypoxic cell radiosensitizer desmethylmisonidazole (Ro 05-Ro-9963) in dogs.乏氧细胞放射增敏剂去甲基米索硝唑（Ro 05-Ro-9963）在犬体内的药代动力学及肿瘤穿透特性

Br J Cancer. 1980 Feb;41(2):268-76. doi: 10.1038/bjc.1980.39.

Enhancement of the effect of cytotoxic drugs by radiosensitizers.放射增敏剂增强细胞毒性药物的作用。

Br J Cancer. 1981 Jun;43(6):756-66. doi: 10.1038/bjc.1981.113.

Low concentrations of misonidazole counteract effects of extreme hypoxia on cells in S.低浓度的米索硝唑可抵消极端缺氧对S期细胞的影响。

Br J Cancer. 1981 Mar;43(3):355-66. doi: 10.1038/bjc.1981.56.

Pharmacokinetic considerations in testing hypoxic cell radiosensitizers in mouse tumours.在小鼠肿瘤中测试乏氧细胞放射增敏剂时的药代动力学考量

Br J Cancer. 1979 Mar;39(3):310-20. doi: 10.1038/bjc.1979.55.

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