Department of Molecular Biology & Diagnosis, ICMR-Vector Control Research Centre , Madurai , India.
Hum Vaccin Immunother. 2019;15(10):2243-2248. doi: 10.1080/21645515.2019.1602431. Epub 2019 May 7.
Kyasanur Forest Disease (KFD) is a tick-borne hemorrhagic fever of human, caused by Kyasanur forest disease virus (KFDV) in India. The tick, , has been incriminated as the vector of KFDV. In human, KFD clinically presents with high fever, frontal headache, and severe myalgia, followed by bleeding from the nasal cavity, throat, gingivae, and in some cases, gastrointestinal tract. The mortality rate in KFDV infected cases is estimated to be 3-10%. Monkeys infected with the virus also develop the disease and die. Though the incidence of KFD was found to be confined only to the sylvatic area of Shimoga district in Karnataka state in India during 1967, recent reports indicate its expanding potential to the neighboring states such as Kerala, Tamil Nadu, and Goa. The administration of an indigenous, inactivated tissue culture vaccine was found to drastically decrease the percentage of incidence; however, the recurrence of KFD in vaccinated subjects warrants innovative strategies for effective control of the infection. The present communication proposes and discusses innovative intervention strategies for the effective prevention and control of KFD in India.
基孔肯雅热（KFD）是一种由印度基孔肯雅森林病毒（KFDV）引起的人血虫媒性出血热。这种蜱虫被认为是 KFDV 的传播媒介。在人类中，KFD 表现为高热、额头痛和严重的肌肉痛，随后鼻腔、喉咙、牙龈出血，在某些情况下还会出现胃肠道出血。感染 KFDV 的病例死亡率估计为 3-10%。感染病毒的猴子也会发病并死亡。尽管 1967 年在印度卡纳塔克邦的希莫加县的森林地区发现了 KFD 的发病率，但最近的报告表明，该病有向喀拉拉邦、泰米尔纳德邦和果阿邦等邻近邦扩展的潜力。使用一种本土的、灭活的组织培养疫苗接种被发现可以大大降低发病率；然而，在接种过疫苗的人群中 KFD 的复发需要创新的策略来有效控制感染。本通讯提出并讨论了印度有效预防和控制 KFD 的创新干预策略。
