Scherwitzl Iris, Mongkolsapaja Juthathip, Screaton Gavin
Department of Medicine, Imperial College London, W12 0NN London, UK.
Department of Medicine, Imperial College London, W12 0NN London, UK; Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Curr Opin Virol. 2017 Apr;23:95-101. doi: 10.1016/j.coviro.2017.04.002. Epub 2017 May 6.
Dengue (DENV), West Nile (WNV) and Zika (ZIKV) viruses are mosquito-transmitted flaviviruses that cause thousands of human deaths and millions of illnesses each year. In the last decades, epidemic outbreaks of all three flaviviruses emerged and caused a major health and economical problem in many parts of the world. The increasing and expanding burden of flaviviruses has highlighted the need for effective human vaccines against all three viruses. This review provides an overview of the recent progress in DENV, WNV and ZIKV vaccines development with specific focus on candidates in human clinical development.
登革热病毒（DENV）、西尼罗河病毒（WNV）和寨卡病毒（ZIKV）是通过蚊子传播的黄病毒，每年导致数千人死亡，数百万人患病。在过去几十年中，这三种黄病毒都出现了疫情爆发，在世界许多地区造成了重大的健康和经济问题。黄病毒日益加重且不断扩大的负担凸显了研发针对这三种病毒的有效人类疫苗的必要性。本综述概述了登革热病毒、西尼罗河病毒和寨卡病毒疫苗研发的最新进展，特别关注处于人体临床开发阶段的候选疫苗。
