Antoun Joelle, Azar Georges, Jabbour Elyse, Kourie Hampig Raphael, Slim Elise, Schakal Alexandre, Jalkh Alex
*Department of Ophthalmology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon; and †Faculty of Medicine, Holy Spirit University of Kaslik, Beirut, Lebanon.
Retina. 2016 Oct;36(10):1906-12. doi: 10.1097/IAE.0000000000001008.
To determine the anatomical and functional outcomes and possible complications after pars plana vitrectomy (PPV) with silicone oil (SO) tamponade in primary uncomplicated rhegmatogenous retinal detachments.
This is a prospective observational study. Overall, 62 consecutive patients who underwent surgical repair by PPV and SO injection for primary uncomplicated rhegmatogenous retinal detachment between January 01, 2006 and April 30, 2012 were followed. In general, PPV was chosen over scleral buckling when a significant cataract or a vitreous hemorrhage prevented adequate fundus visualization. Silicone oil was chosen over gas tamponade in patients living at 1,000 meters above the sea level, where SF6 or C3F8 tamponade could not be performed because of the risk of acute increase of intraocular pressure (IOP). One thousand centistokes SO was used in all eyes. At all visits, patients had a detailed ocular history and thorough bilateral evaluation, including best-corrected visual acuity, anterior segment examination, and IOP measurements by aplanation and fundus examination. Outcomes were assessed at 1 day, 1 week, 1 month, 3 months, 6 months, and every 6 months thereafter. Increased IOP was defined as an IOP of more than 21 mmHg.
Anatomical success rate, final best-corrected visual acuity, IOP elevation, cataract formation, and other complications were the main outcome measures. This study included 62 eyes of 62 patients (41 men and 21 women) that underwent retinal detachment repair by PPV and SO injection. The age at the time of intervention was 57.6 ± 10.5 years (mean ± standard deviation; range, 34-79 years). All patients were whites. Mean follow-up was 24.5 ± 17.3 months (range, 6-70 months). Anatomical success rate defined as retinal reattachment 6 months after SO removal was 93.5%. Final BCVA was improved in 55 eyes (88.7%), with a mean of 4 Snellen lines, unchanged in 5 (8.1%), and worse in 2 eyes (3.2%), with a mean of 3 Snellen lines. Mean duration of SO tamponade was 5.12 ± 2.37 months (range, 2-12 months). From the 30 eyes that were still phakic after vitrectomy, 24 eyes (80.0%) underwent cataract surgery within a period of 7.37 ± 3.00 months (range, 2-13 months). Thirty-five eyes (56.5%) had an increase in IOP during the follow-up period. Thirty-one patients had transient ocular hypertension requiring topical treatment during the immediate postoperative period (one month). Only 1 eye (2.9%) required filtrating drainage surgery for IOP control. No eyes developed optic neuropathy secondary to IOP elevation.
Pars plana vitrectomy with SO injection seems to be a safe and efficient surgical approach in the treatment of primary uncomplicated rhegmatogenous retinal detachment in patients living in high altitude (>1,000 m). Also, PPV and SO injection are associated with good anatomical and functional outcomes in our series. Reattachment rates are high, and rates of proliferative vitreoretinopathy are low. Cataract formation and elevated IOP represent frequent but successfully controlled complications.
确定在原发性单纯孔源性视网膜脱离患者中,行玻璃体切除术(PPV)联合硅油(SO)填充后的解剖和功能结果以及可能的并发症。
这是一项前瞻性观察性研究。对2006年1月1日至2012年4月30日期间连续62例因原发性单纯孔源性视网膜脱离接受PPV联合SO注射手术修复的患者进行随访。一般来说,当存在明显白内障或玻璃体积血妨碍充分的眼底观察时,选择PPV而非巩膜扣带术。对于居住在海拔1000米以上的患者,由于存在眼内压(IOP)急性升高的风险而无法进行六氟化硫(SF6)或八氟环丁烷(C3F8)填充时,选择硅油而非气体填充。所有眼均使用1000厘沲的硅油。在每次随访时,患者均有详细的眼部病史并接受全面的双侧评估,包括最佳矫正视力、眼前节检查以及通过压平眼压计测量眼压和眼底检查。在术后1天、1周、1个月、3个月、6个月以及此后每6个月评估结果。IOP升高定义为眼压超过21 mmHg。
解剖成功率、最终最佳矫正视力、IOP升高、白内障形成及其他并发症为主要观察指标。本研究纳入62例患者的62只眼(41例男性和21例女性),这些患者均接受了PPV联合SO注射的视网膜脱离修复手术。干预时的年龄为57.6±10.5岁(平均值±标准差;范围34 - 79岁)。所有患者均为白人。平均随访时间为24.5±17.3个月(范围6 - 70个月)。以硅油取出后6个月视网膜复位定义的解剖成功率为93.5%。55只眼(88.7%)的最终最佳矫正视力得到改善,平均提高4行Snellen视力表视力;5只眼(8.1%)视力无变化;2只眼(3.2%)视力下降,平均下降3行Snellen视力表视力。硅油填充的平均持续时间为5.12±2.37个月(范围2 - 12个月)。在玻璃体切除术后仍为晶状体眼的30只眼中,24只眼(80.0%)在7.37±3.00个月(范围2 - 13个月)内接受了白内障手术。35只眼(56.5%)在随访期间IOP升高。31例患者在术后即刻(1个月)出现短暂性高眼压,需要局部治疗。仅1只眼(2.9%)需要行滤过性引流手术来控制眼压。没有眼因IOP升高而发生视神经病变。
对于居住在高海拔地区(>1000米)的原发性单纯孔源性视网膜脱离患者,PPV联合SO注射似乎是一种安全有效的手术方法。此外,在我们的研究系列中,PPV联合SO注射具有良好的解剖和功能结果。复位率高,增生性玻璃体视网膜病变发生率低。白内障形成和IOP升高是常见但可成功控制的并发症。