a Department of Immunology-Allergology-Rheumatology , Antwerp University Hospital, University of Antwerp , Antwerp , Belgium.
b Department of Pediatrics , Antwerp University Hospital, University of Antwerp , Antwerp , Belgium.
Expert Rev Clin Immunol. 2019 Jun;15(6):599-606. doi: 10.1080/1744666X.2019.1600403. Epub 2019 Apr 4.
Although the use of cannabis dates back millennia, the first description of cannabis allergy is relatively recent (1971). Recent large-scale data show that cannabis allergy can manifest severe and generalized symptoms with extensive cross-reactions. Thus, it is essential to become familiarized with its clinical presentation, diagnostic aids, and adequate therapeutic guidance. Areas covered: Here we provide a hands-on overview on cannabis allergy focusing on symptomatology and the reliability of diagnostic options. Recent advances in proteomics are discussed in detail, elucidating the link with nsLTP-related allergies. The proteomics advancements have paved the way for more reliable diagnostics, especially component-based tools. Finally, the current experience in treatment options is highlighted. Expert opinion: Cannabis allergy is an allergy entity which can significantly impact the quality of life. For optimal diagnosis, we advise to start with a validated and standardized crude-extract based test such as sIgE hemp complemented by component-based diagnostics such as sIgE Can s 3 quantifications where available. Future research should lift the veil on the true prevalence of cannabis allergy and the importance of other cannabis allergens to further guide our practice.
尽管大麻的使用可以追溯到几千年前，但大麻过敏的第一个描述相对较新（1971 年）。最近的大规模数据表明，大麻过敏会表现出严重和广泛的症状，并伴有广泛的交叉反应。因此，熟悉其临床表现、诊断辅助手段和适当的治疗指导至关重要。涵盖领域：在这里，我们提供了一个关于大麻过敏的实用概述，重点介绍了症状和诊断选择的可靠性。详细讨论了蛋白质组学的最新进展，阐明了其与 nsLTP 相关过敏的联系。蛋白质组学的进步为更可靠的诊断铺平了道路，特别是基于成分的工具。最后，突出了当前治疗选择的经验。专家意见：大麻过敏是一种会显著影响生活质量的过敏实体。为了获得最佳诊断，我们建议首先使用基于经过验证和标准化的粗提取物的测试，例如 hemp sIgE，同时结合基于成分的诊断，例如在有条件的情况下进行 Can s 3 定量 sIgE。未来的研究应该揭示大麻过敏的真实流行率以及其他大麻过敏原的重要性，以进一步指导我们的实践。
