从迎春花茎中分离得到的四个具有抗炎活性的倍半萜。
Four new sesquiterpenoids with anti-inflammatory activity from the stems of Jasminum officinale.
机构信息
The Ministry of Education Key Laboratory for Standardization of Chinese Medicines, The State Administration of Traditional Chinese Medicine Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Shanghai R&D Center for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
The Ministry of Education Key Laboratory for Standardization of Chinese Medicines, The State Administration of Traditional Chinese Medicine Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Shanghai R&D Center for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
出版信息
Fitoterapia. 2019 Jun;135:22-26. doi: 10.1016/j.fitote.2019.03.029. Epub 2019 Apr 1.
Four new sesquiterpenoids，including three nor-cinalbicane type sesquiterpenoids, named Jasminol A, G, H (1-3) and one eremophilene-type sesquiterpenoid, named Jasminol B (4) together with nine known compounds (5-13) were isolated from the stems of Jasminum officinale L. The structures of new compound were elucidated on the base of IR, HR-ESI-MS, 1D NMR, 2D NMR and DEPT analysis, and the absolute configurations were determined by single-crystal X-ray diffraction analysis. In addition, the anti-inflammatory activity of isolated compounds was evaluated using lipopolysaccharide (LPS)-induced murine macrophage RAW264.7, and compounds 1-4 exhibited a moderate inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 cells with IC values of 20.56 ± 1.31, 30.12 ± 0.89, 30.35 ± 2.72 and 31.60 ± 1.69 μM, respectively, and CC values >200 uM.
从木樨科素馨属植物迎春花 Jasminum officinale L. 的茎中分离得到了 4 个新的倍半萜类化合物，包括 3 个属于诺古卡烷型倍半萜的化合物 Jasminol A、G、H（1-3）和 1 个属于埃雷莫芬烷型倍半萜的化合物 Jasminol B（4），以及 9 个已知化合物（5-13）。根据 IR、HR-ESI-MS、1D NMR、2D NMR 和 DEPT 分析，确定了新化合物的结构，并通过单晶 X 射线衍射分析确定了其绝对构型。此外，还评价了分离得到的化合物对脂多糖（LPS）诱导的小鼠巨噬细胞 RAW264.7 的抗炎活性，化合物 1-4 对 LPS 诱导的 RAW264.7 细胞中一氧化氮（NO）的产生具有中等抑制作用，IC50 值分别为 20.56±1.31、30.12±0.89、30.35±2.72 和 31.60±1.69 μM，CC50 值均大于 200 μM。
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