黄花蒿中的去氢木香内酯倍半萜及其抗炎活性。
Noreudesmane sesquiterpenoids from Artemisia hedinii and their anti-inflammatory activities.
机构信息
State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.
State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
出版信息
Fitoterapia. 2021 Sep;153:104961. doi: 10.1016/j.fitote.2021.104961. Epub 2021 Jun 12.
Ten undescribed noreudesmane-type sesquiterpenoids, including eight 12,13-dinoreudesmanes and a pair of 11,12,13-trinoreudesmane epimers were isolated from the whole plant of Artemisia hedinii. Their structures were elucidated by extensive analysis of spectroscopic data, including MS, 1D and 2D NMR, and their absolute configurations were confirmed by X-ray diffraction experiments and DFT calculations. Compounds 1-5, 7-10 were evaluated for their anti-inflammatory activities in lipopolysaccharide (LPS)-stimulated murine macrophages RAW264.7 cells, and all of them could significantly inhibit the LPS induced CCL2 mRNA expression in a dose-dependent manner.
从 Artemisia hedinii 的全草中分离得到了 10 种未描述的 noreudesmane 型倍半萜，包括 8 种 12,13-二去氢 noreudesmanes 和一对 11,12,13-三去氢 noreudesmane 差向异构体。通过广泛的光谱数据分析，包括 MS、1D 和 2D NMR，阐明了它们的结构，其绝对构型通过 X 射线衍射实验和 DFT 计算得到了确证。化合物 1-5、7-10 被评估了它们在脂多糖 (LPS) 刺激的小鼠巨噬细胞 RAW264.7 细胞中的抗炎活性，它们都能以剂量依赖的方式显著抑制 LPS 诱导的 CCL2 mRNA 表达。
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