冠状动脉疾病中前蛋白转化酶枯草杆菌蛋白酶/kexin 9型基因的变异
Variations of the proprotein convertase subtilisin/kexin type 9 gene in coronary artery disease.
作者信息
Chiang Shih-Min, Yang Yi-Sun, Yang Shun-Fa, Tsai Chin-Feng, Ueng Kwo-Chnag
机构信息
Institute of Medicine, Chung Shan Medical University, Taichung.
Department of Internal Medicine, Division of Endocrinology and Metabolism, Chung-Shan Medical University Hospital, Taichung.
出版信息
J Int Med Res. 2020 Jan;48(1):300060519839519. doi: 10.1177/0300060519839519. Epub 2019 Apr 5.
OBJECTIVE
Coronary artery disease (CAD) is the principal cause of mortality and morbidity worldwide. Studies have provided controversial results regarding whether variations in the proprotein convertase subtilisin/kexin type 9 gene () are risk factors for CAD. In this study, we evaluated the risk factors associated with genotypes and CAD in the Taiwanese population.
METHODS
A total of 501 patients diagnosed with CAD by angiography and 334 CAD-free controls were recruited. Two single nucleotide polymorphisms of (rs505151 and rs529787) were genotyped.
RESULTS
The prevalence of a positive family history for CAD was significantly higher in individuals carrying the AG + GG genotype of the rs505151 polymorphism. Among CAD patients with a positive family history, the prevalence of diabetes mellitus was significantly higher in those carrying the AG + GG genotype of the rs505151 polymorphism (73.3%) than in those carrying the AA genotype (39.2%).
CONCLUSION
In CAD patients, the AG genotype of rs505151 is associated with diabetes and a positive family history of CAD.
目的
冠状动脉疾病（CAD）是全球范围内死亡和发病的主要原因。关于前蛋白转化酶枯草杆菌蛋白酶/kexin 9型基因（）的变异是否为CAD的危险因素，研究结果存在争议。在本研究中，我们评估了台湾人群中与基因分型和CAD相关的危险因素。
方法
共招募了501例经血管造影诊断为CAD的患者和334例无CAD的对照。对基因的两个单核苷酸多态性（rs505151和rs529787）进行基因分型。
结果
携带rs505151多态性AG + GG基因型的个体中，CAD阳性家族史的患病率显著更高。在有CAD阳性家族史的患者中，携带rs505151多态性AG + GG基因型的患者（73.3%）糖尿病患病率显著高于携带AA基因型的患者（39.2%）。
结论
在CAD患者中，rs505151的AG基因型与糖尿病和CAD阳性家族史相关。
Zotero 插件