基因变异与墨西哥人的亚临床动脉粥样硬化和心脏代谢参数相关。GEA项目。
Variants of Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project.
作者信息
Zamarrón-Licona Erasmo, Rodríguez-Pérez José Manuel, Posadas-Sánchez Rosalinda, Vargas-Alarcón Gilberto, Baños-González Manuel Alfonso, Borgonio-Cuadra Verónica Marusa, Pérez-Hernández Nonanzit
机构信息
Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico.
Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico.
出版信息
Diagnostics (Basel). 2021 Apr 26;11(5):774. doi: 10.3390/diagnostics11050774.
BACKGROUND
Coronary artery disease (CAD) is a chronic, inflammatory, and complex disease associated with vascular risk factors. Nowadays, the coronary artery calcium (CAC) is a specific marker of the presence and extent of atherosclerosis. Additionally, CAC is a predictor of future coronary events in asymptomatic individuals diagnosed with subclinical atherosclerosis (CAC > 0). In this study, our aim is to evaluate the participation of two polymorphisms of the gene as genetic markers for developing subclinical atherosclerosis and cardiometabolic risk factors in asymptomatic individuals.
METHODS
We analyzed two PCSK9 polymorphisms (rs2479409 and rs615563) in 394 individuals with subclinical atherosclerosis and 1102 healthy controls using real time- polymerase chain reaction (PCR).
RESULTS
Under various inheritance models adjusted for different confounding factors, the rs2479409 polymorphism was associated with an increased risk of developing subclinical atherosclerosis (OR = 1.53, P recessive = 0.041). Both polymorphisms were significantly associated with several cardiometabolic parameters.
CONCLUSIONS
Our data suggest that rs2479409 polymorphism could be envisaged as a risk marker for subclinical atherosclerosis.
背景
冠状动脉疾病（CAD）是一种与血管危险因素相关的慢性、炎症性和复杂性疾病。如今，冠状动脉钙化（CAC）是动脉粥样硬化存在和程度的特异性标志物。此外，CAC是诊断为亚临床动脉粥样硬化（CAC>0）的无症状个体未来发生冠状动脉事件的预测指标。在本研究中，我们的目的是评估该基因的两种多态性作为无症状个体发生亚临床动脉粥样硬化和心脏代谢危险因素的遗传标志物的作用。
方法
我们使用实时聚合酶链反应（PCR）分析了394例亚临床动脉粥样硬化个体和1102例健康对照中的两种前蛋白转化酶枯草溶菌素9（PCSK9）多态性（rs2479409和rs615563）。
结果
在针对不同混杂因素进行调整的各种遗传模型下，rs2479409多态性与发生亚临床动脉粥样硬化的风险增加相关（比值比=1.53，隐性遗传模型下P=0.041）。两种多态性均与多个心脏代谢参数显著相关。
结论
我们的数据表明，rs2479409多态性可被视为亚临床动脉粥样硬化的风险标志物。
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