Deshpande Ravindra Pramod, Y B V K Chandrasekhar, Panigrahi Manas, Babu Phanithi Prakash
1Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana State 500046 India.
2Krishna Institute of Medical Sciences, Secunderabad, Telangana State India.
Indian J Surg Oncol. 2019 Mar;10(1):55-60. doi: 10.1007/s13193-018-0820-0. Epub 2018 Oct 30.
Astrocytoma constitutes the most noted malignancies of the central nervous system with worse clinical outcomes in grade IV astrocytoma or glioblastoma multiforme. Owing to poor clinical outcomes with existing therapeutic regime, there is a need to revisit the initial course of treatment. Statistical information of clinicopathological parameters could be used to understand the spread of disease and, in turn, to formulate updated treatment management. In the present study, we have seen anatomic distribution of astrocytoma subtypes in a group of 479 patients and correlated it with survival outcomes. Anatomic location was confirmed by MRI (magnetic resonance imaging) images. A registry of patients was maintained with clinicopathological details as tumor type, location, age/sex, and survival after surgery. We have observed overall survival particulars in patients diagnosed with astrocytoma. Our findings highlight that in total cases, tumor location was anatomically dominated by frontal and temporal lobes. Survival analysis in high-grade (grade III, = 0.03; grade IV, = 0.01) astrocytic tumors confirms poor outcomes with temporal, parietal, and occipital location as compared to frontal lobe. Overall survival study demonstrates glioblastoma multiforme (GBM) was associated with worse prognosis as compared to astrocytoma subtypes ( < 0.0001). In high-grade astrocytomas, anaplastic astrocytoma was found with 34 months of median survival age while 14 months in the case of patients with glioblastoma multiforme. In conclusion, we report dismal prognosis in parietal, temporal, and occipital lobes in grade II, grade III, and grade IV astrocytoma patients. Among astrocytoma subtypes, patients with glioblastoma multiforme were associated with worse survival outcomes. We uniquely feature the survival of astrocytoma patients for the first time and observe GBM patients have slightly longer survival.
星形细胞瘤是中枢神经系统最常见的恶性肿瘤，IV级星形细胞瘤或多形性胶质母细胞瘤的临床预后较差。由于现有治疗方案的临床效果不佳，有必要重新审视初始治疗方案。临床病理参数的统计信息可用于了解疾病的扩散情况，进而制定更新的治疗管理方案。在本研究中，我们观察了479例患者星形细胞瘤亚型的解剖分布，并将其与生存结果相关联。解剖位置通过MRI（磁共振成像）图像确定。建立了一个患者登记册，记录肿瘤类型、位置、年龄/性别和手术后生存等临床病理细节。我们观察了诊断为星形细胞瘤患者的总体生存情况。我们的研究结果表明，在所有病例中，肿瘤位置在解剖学上以额叶和颞叶为主。高级别（III级，P = 0.03；IV级，P = 0.01）星形细胞瘤的生存分析证实，与额叶相比，颞叶、顶叶和枕叶位置的预后较差。总体生存研究表明，与星形细胞瘤亚型相比，多形性胶质母细胞瘤（GBM）的预后更差（P < 0.0001）。在高级别星形细胞瘤中，间变性星形细胞瘤的中位生存年龄为34个月，而多形性胶质母细胞瘤患者为14个月。总之，我们报告II级、III级和IV级星形细胞瘤患者的顶叶、颞叶和枕叶预后不佳。在星形细胞瘤亚型中，多形性胶质母细胞瘤患者的生存结果更差。我们首次独特地描述了星形细胞瘤患者的生存情况，并观察到GBM患者的生存时间略长。
