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1
Natural killer and antibody-dependent cellular cytotoxicity in cervical carcinoma patients.宫颈癌患者的自然杀伤细胞及抗体依赖性细胞毒性作用
Cancer Immunol Immunother. 1986;23(1):56-9. doi: 10.1007/BF00205556.
2
Natural killer cell activity in the rat. VI. Characterization of rat large granular lymphocytes as effector cells in natural killer and antibody-dependent cellular cytotoxic activities.大鼠自然杀伤细胞活性。VI. 大鼠大颗粒淋巴细胞作为自然杀伤和抗体依赖性细胞毒性活性效应细胞的特性。
J Leukoc Biol. 1987 Feb;41(2):130-42. doi: 10.1002/jlb.41.2.130.
3
Characteristics of human large granular lymphocytes and relationship to natural killer and K cells.人类大颗粒淋巴细胞的特征及其与自然杀伤细胞和K细胞的关系。
J Exp Med. 1981 Mar 1;153(3):569-82. doi: 10.1084/jem.153.3.569.
4
Effect of bitter melon (Momordica charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy.苦瓜（苦瓜属 Linn）对宫颈癌放疗患者自然杀伤细胞水平及功能的影响。
J Med Assoc Thai. 2003 Jan;86(1):61-8.
5
Characterization and utilization of a monoclonal antibody inhibiting porcine natural killer cell activity for isolation of natural killer and killer cells.一种抑制猪自然杀伤细胞活性的单克隆抗体的特性鉴定及利用，用于分离自然杀伤细胞和杀伤细胞。
J Immunol. 1990 Jun 1;144(11):4452-62.
6
Mechanism of defective NK cell activity in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. II. Normal antibody-dependent cellular cytotoxicity (ADCC) mediated by effector cells defective in natural killer (NK) cytotoxicity.获得性免疫缺陷综合征（AIDS）及AIDS相关综合征患者自然杀伤（NK）细胞活性缺陷的机制。II. 由自然杀伤细胞（NK）细胞毒性缺陷的效应细胞介导的正常抗体依赖性细胞毒性（ADCC）
J Immunol. 1987 Jul 1;139(1):55-60.
7
IFN-α augments natural killer-mediated antibody-dependent cellular cytotoxicity of HIV-1-infected autologous CD4+ T cells regardless of major histocompatibility complex class 1 downregulation.无论主要组织相容性复合体I类下调情况如何，干扰素-α均可增强自然杀伤细胞介导的HIV-1感染的自体CD4+ T细胞的抗体依赖性细胞毒性。
AIDS. 2017 Mar 13;31(5):613-622. doi: 10.1097/QAD.0000000000001380.
8
Chédiak-Higashi gene in humans. II. The selectivity of the defect in natural-killer and antibody-dependent cell-mediated cytotoxicity function.人类的Chédiak-Higashi基因。II. 自然杀伤细胞和抗体依赖性细胞介导的细胞毒性功能缺陷的选择性
J Exp Med. 1980 May 1;151(5):1049-58. doi: 10.1084/jem.151.5.1049.
9
No alteration in NK function or zeta chain expression in NK and T cells of cervical cancer patients.宫颈癌患者自然杀伤细胞（NK）和T细胞的NK功能或ζ链表达无改变。
Gynecol Oncol. 2003 Apr;89(1):120-8. doi: 10.1016/s0090-8258(03)00009-x.
10
Defective natural killing activity but retention of lymphocyte-mediated antibody-dependent cellular cytotoxicity in patients with the X-linked lymphoproliferative syndrome.X连锁淋巴增殖综合征患者存在自然杀伤活性缺陷，但保留淋巴细胞介导的抗体依赖性细胞毒性。
Cell Immunol. 1986 Jun;100(1):1-9. doi: 10.1016/0008-8749(86)90001-8.

引用本文的文献

1
Prognostic Value of Circulating Lymphocyte Subsets in Cervical Cancer Following Postoperative Radiotherapy.术后放疗后宫颈癌患者循环淋巴细胞亚群的预后价值
Int J Med Sci. 2025 Feb 3;22(5):1029-1038. doi: 10.7150/ijms.107392. eCollection 2025.
2
Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach.采用新型综合方法在宫颈癌患者放化疗期间保留免疫功能。
Brain Behav Immun. 2010 Nov;24(8):1231-40. doi: 10.1016/j.bbi.2010.06.014. Epub 2010 Jun 30.
3
In vitro modulation of natural killer cell activity in non-Hodgkin's lymphoma patients after therapy.非霍奇金淋巴瘤患者治疗后自然杀伤细胞活性的体外调节
Cancer Immunol Immunother. 1989;28(2):148-52. doi: 10.1007/BF00199116.

本文引用的文献

1
Prospective study of natural cytotoxicity in peripheral blood of patients with nonlymphoid solid malignancies.非淋巴样实体恶性肿瘤患者外周血自然细胞毒性的前瞻性研究。
Clin Immunol Immunopathol. 1984 Apr;31(1):78-86. doi: 10.1016/0090-1229(84)90191-0.
2
Natural cytotoxicity of lymphocytes from lymph nodes draining breast carcinoma and its augmentation by interferon and OK432.乳腺癌引流淋巴结淋巴细胞的自然细胞毒性及其通过干扰素和OK432的增强作用。
Cancer Immunol Immunother. 1984;17(1):1-6. doi: 10.1007/BF00205490.
3
Natural killer-interferon system in patients with preleukaemic states.白血病前期患者的自然杀伤细胞-干扰素系统
Br J Haematol. 1984 Sep;58(1):71-81. doi: 10.1111/j.1365-2141.1984.tb06060.x.
4
Decreased natural killer cell activity and interferon production by leucocytes in patients with adenocarcinoma of the pancreas.胰腺癌患者体内自然杀伤细胞活性降低，白细胞产生干扰素的能力下降。
Br J Cancer. 1984 Aug;50(2):231-3. doi: 10.1038/bjc.1984.168.
5
Lysis of fresh human tumor cells by autologous large granular lymphocytes and T-lymphocytes: two distinct killing activities induced by coculture with autologous tumor.自体大颗粒淋巴细胞和T淋巴细胞对新鲜人肿瘤细胞的裂解作用：与自体肿瘤共培养诱导的两种不同杀伤活性。
J Natl Cancer Inst. 1984 Dec;73(6):1285-92.
6
Defects in natural killer cell activity and interferon response in human lung carcinoma and malignant melanoma.人类肺癌和恶性黑色素瘤中自然杀伤细胞活性及干扰素反应的缺陷。
Cancer Res. 1984 Feb;44(2):852-6.
7
Natural cytotoxicity in malignant and premalignant cervical neoplasia and enhancement of cytotoxicity with interferon.恶性及癌前宫颈肿瘤中的自然细胞毒性以及干扰素对细胞毒性的增强作用。
Gynecol Oncol. 1983 Jun;15(3):340-9. doi: 10.1016/0090-8258(83)90051-3.
8
Immunoregulation and natural killer cells.免疫调节与自然杀伤细胞
Mol Immunol. 1982 Oct;19(10):1313-21. doi: 10.1016/0161-5890(82)90299-1.
9
Natural cytotoxicity and interferon production in human cancer: deficient natural killer activity and normal interferon production in patients with advanced disease.人类癌症中的自然细胞毒性和干扰素产生：晚期疾病患者自然杀伤活性缺陷及干扰素产生正常。
J Immunol. 1981 Nov;127(5):1817-22.
10
Characteristics of human large granular lymphocytes and relationship to natural killer and K cells.人类大颗粒淋巴细胞的特征及其与自然杀伤细胞和K细胞的关系。
J Exp Med. 1981 Mar 1;153(3):569-82. doi: 10.1084/jem.153.3.569.

宫颈癌患者的自然杀伤细胞及抗体依赖性细胞毒性作用

Natural killer and antibody-dependent cellular cytotoxicity in cervical carcinoma patients.

作者信息

Satam M N, Suraiya J N, Nadkarni J J

出版信息

Cancer Immunol Immunother. 1986;23(1):56-9. doi: 10.1007/BF00205556.

DOI:10.1007/BF00205556
PMID:3094944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038408/
Abstract

Natural killer (NK) cell activity and antibody dependent cell-mediated cytotoxicity (ADCC) was measured in 62 untreated cervical carcinoma patients and 25 normal healthy women, using a short-term chromium release assay. A significant reduction in NK and ADCC activity was observed in disseminated disease than in localized disease, when compared with normal donors. The majority of the patients received radiotherapy and both NK and ADCC activity recovered after therapy. Furthermore, interferon-alpha was demonstrated to augment NK activity of peripheral blood mononuclear cells from healthy donors as well as patients. Also large granular lymphocytes separated on Percoll density gradient were the same in number in both the populations studied, although in cervical cancer there seemed to be a defect in killing activity.

摘要

采用短期铬释放试验，对62例未经治疗的宫颈癌患者和25名正常健康女性的自然杀伤（NK）细胞活性及抗体依赖性细胞介导的细胞毒性（ADCC）进行了检测。与正常供体相比，发现播散性疾病患者的NK和ADCC活性较局限性疾病患者显著降低。大多数患者接受了放射治疗，治疗后NK和ADCC活性均恢复。此外，已证实α干扰素可增强健康供体以及患者外周血单个核细胞的NK活性。尽管在宫颈癌患者中杀伤活性似乎存在缺陷，但通过Percoll密度梯度分离的大颗粒淋巴细胞在两组研究人群中的数量相同。