一名接受抗逆转录病毒治疗且长期抑制HIV-1病毒载量的患者发生HIV-2双重感染
Human Immunodeficiency Virus (HIV) 2 Superinfection in a Patient Receiving Antiretroviral Therapy With Longstanding HIV-1 Viral Load Suppression.
作者信息
Ceia F, Silva-Pinto A, Carvalho A C, Piñeiro C, Soares J, Serrão R, Sarmento A
机构信息
Infectious Diseases Department, Centro Hospitalar São João, Porto, University of Porto, Portugal.
Faculty of Medicine, University of Porto, University of Porto, Portugal.
出版信息
Open Forum Infect Dis. 2019 Feb 12;6(4):ofz063. doi: 10.1093/ofid/ofz063. eCollection 2019 Apr.
Dual human immunodeficiency virus (HIV) 1 and HIV-2 superinfections are rare but challenging. A HIV-1-infected patient receiving effective antiretroviral therapy was investigated for a severe CD4 cell count decline. HIV-2 superinfection was diagnosed and genotypic test revealed mutations conferring resistance to most drug class, limiting options for treatment.
人类免疫缺陷病毒（HIV）1型和HIV - 2型双重感染罕见但具有挑战性。一名接受有效抗逆转录病毒治疗的HIV - 1感染患者因CD4细胞计数严重下降而接受调查。诊断为HIV - 2重叠感染，基因检测显示存在对大多数药物类别耐药的突变，限制了治疗选择。
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