在实际临床实践中，比较两种合并症指数对慢性阻塞性肺疾病患者的预后预测能力。
Comparison of the prognostic capability of two comorbidity indices in patients with chronic obstructive pulmonary disease, in real-life clinical practice.
作者信息
Figueira-Gonçalves Juan Marco, Golpe Rafael, García-Bello Miguel Ángel, García-Talavera Ignacio, Castro-Añón Olalla
机构信息
Pneumology and Thoracic Surgery Service, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
Pneumology Service, University Hospital Lucus Augusti, Lugo, Spain.
出版信息
Clin Respir J. 2019 Jun;13(6):404-407. doi: 10.1111/crj.13025. Epub 2019 Apr 24.
BACKGROUND
Comorbidities are a major cause of death in chronic obstructive pulmonary disease (COPD). The COPD-comorbidity test (COTE) index was designed to measure comorbidity burden in this disease. The objective of this study was to compare the capability of COTE and the non-COPD specific Charlson comorbidity index (CCI) to predict all-cause mortality in real-life conditions.
METHODS
Retrospective observational study, carried out in two different series of consecutive COPD patients including, respectively, 790 and 439 subjects. The COTE and non-age-adjusted CCI indices were calculated and the values of the C-statistic for predicting all-cause mortality were compared for both indices.
RESULTS
Median follow-up was 54 months and there were 321 deaths within this period of time. The value of the C-statistic for the CCI was significantly higher than for the COTE index in both groups.
CONCLUSION
When used in real-life clinical practice, the value of the CCI to predict all-cause mortality in COPD seems higher than that of the COTE index.
背景
合并症是慢性阻塞性肺疾病（COPD）患者死亡的主要原因。COPD合并症检测（COTE）指数旨在衡量该疾病的合并症负担。本研究的目的是比较COTE指数与非COPD特异性的Charlson合并症指数（CCI）在实际情况下预测全因死亡率的能力。
方法
在两组不同的连续COPD患者系列中进行回顾性观察研究，分别包括790例和439例受试者。计算COTE指数和未调整年龄的CCI指数，并比较两个指数预测全因死亡率的C统计量值。
结果
中位随访时间为54个月，在此期间有321例死亡。两组中，CCI的C统计量值均显著高于COTE指数。
结论
在实际临床实践中，CCI预测COPD患者全因死亡率的价值似乎高于COTE指数。
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