von Zabern I, Nolte R
Complement. 1986;3(2):97-104. doi: 10.1159/000467885.
Incubation of normal human serum with 3-5 mM Mergetpa causes activation of the alternative pathway of complement as indicated by fragmentation of C3 and factor B, dependent on the presence of divalent cations. Mergetpa inhibits the regulatory protein factor I and, as a consequence, may allow initiation of the feedback cycle of the alternative pathway by deregulation. The classical pathway is not or only to a minor extent activated. A decrease in the hemolytic activity of C2, C5 and one or several of the components C6-9 in the presence of 5 mM Mergetpa may be explained by direct inactivation. The described effects are probably mediated by Mergetpa acting as a thiol.
正常人血清与3 - 5 mM的Mergetpa孵育会导致补体替代途径的激活，表现为C3和B因子的片段化，这依赖于二价阳离子的存在。Mergetpa抑制调节蛋白因子I，因此，可能通过解除调节来启动替代途径的反馈循环。经典途径未被激活或仅在很小程度上被激活。在5 mM Mergetpa存在的情况下，C2、C5以及C6 - 9中的一种或几种成分的溶血活性降低可能是由于直接失活所致。上述作用可能是由作为硫醇的Mergetpa介导的。
