von Zabern I, Nolte R
Abteilung Biochemische Pharmakologie, Max-Planck-Institut für experimentelle Medizin, Göttingen, BRD.
Int Arch Allergy Appl Immunol. 1987;84(2):178-84. doi: 10.1159/000234420.
Thiol-containing drugs (dimercaprol, dimercaptopropanesulfonate, captopril, penicillamine, N-acetylcysteine) and the standard reducing agent beta-mercaptoethanol, activate the alternative pathway of complement as shown by in vitro experiments. Depending on the substance tested, at concentrations of 0.5-5 mM, cleavage products of C3 and factor B were demonstrable in serum by immunoelectrophoresis. The regulatory protein factor I proved to be very sensitive to thiols; this observation offers an explanation for the alternative pathway activating effect of these substances. At concentrations of thiols that initiate the alternative pathway, the classical pathway was not or only to a minor extent activated; however, the activity of C2, C5 and one or several of the components C6-9 was directly affected. Alkylation of the thiol group of the compounds tested, abrogated their effects on the complement system.
含硫醇药物（二巯丙醇、二巯基丙磺酸钠、卡托普利、青霉胺、N - 乙酰半胱氨酸）以及标准还原剂β - 巯基乙醇，体外实验表明它们可激活补体替代途径。根据所测试的物质不同，在0.5 - 5 mM的浓度下，通过免疫电泳可在血清中检测到C3和B因子的裂解产物。调节蛋白I因子被证明对硫醇非常敏感；这一观察结果为这些物质的替代途径激活作用提供了解释。在启动替代途径的硫醇浓度下，经典途径未被激活或仅在很小程度上被激活；然而，C2、C5以及C6 - 9中的一种或几种成分的活性受到直接影响。所测试化合物的硫醇基团烷基化后，消除了它们对补体系统的影响。
