脊索瘤：基于解剖部位的组织病理学研究。
Chordomas: Histopathological Study in View of Anatomical Location.
机构信息
Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Department of Pathology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea.
出版信息
J Korean Med Sci. 2019 Apr 8;34(13):e107. doi: 10.3346/jkms.2019.34.e107.
BACKGROUND
Chordomas are aggressive bone tumors that have a predilection for the axial skeleton including the skull base and spinal/sacral bones. However, the histopathological and clinical differences between skull base chordoma (SBC) and sacral/spinal chordoma (SC) are unclear as previous studies have been focused on patient prognosis and treatment outcome. This study aimed to evaluate the clinicopathologic features and prognosis of chordoma according to its location.
METHODS
Patients with chordomas were enrolled, and the histopathologic features were compared according to the tumor location.
RESULTS
A total of 52 patients were enrolled. SBCs had more abundant chondroid matrix and diffuse growth pattern, while SCs had non-chondroid, myxoid matrix and a lobulating pattern, typical of chordoma. Old age and residual tumors were risk factors for shorter overall survival in SBCs. The chondroid matrix was an independent risk factor for shorter disease-free survival in the overall population.
CONCLUSION
Chordomas have different histopathologic features depending on the anatomical location.
背景
脊索瘤是一种侵袭性骨肿瘤，好发于包括颅底和脊柱/骶骨在内的中轴骨骼。然而，由于既往研究主要集中在患者预后和治疗结果上，因此颅底脊索瘤（SBC）和骶骨/脊柱脊索瘤（SC）之间的组织病理学和临床差异尚不清楚。本研究旨在根据肿瘤位置评估脊索瘤的临床病理特征和预后。
方法
入组脊索瘤患者，并根据肿瘤位置比较组织病理学特征。
结果
共入组 52 例患者。SBC 具有更丰富的软骨样基质和弥漫性生长模式，而 SC 具有非软骨样、黏液样基质和分叶状模式，这些都是典型的脊索瘤特征。高龄和肿瘤残留是 SBC 患者总生存期较短的危险因素。软骨样基质是总体人群无病生存期较短的独立危险因素。
结论
脊索瘤根据解剖位置具有不同的组织病理学特征。
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