Suzhou Engineering and Technological Research Center of Natural Medicine and Functional Food, Institute of Pharmaceutical Biotechnology, School of Biological and Food Engineering, Suzhou University, 49, Bianhe Road, Suzhou, 234000, China.
Department of Clinical Laboratory, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002, China.
Curr Mol Med. 2019;19(4):303-314. doi: 10.2174/1566524019666190405094125.
Compound Fengshiding capsule (CFC), is a Chinese formulation from herbal origin including Alangium platanifolium, Angelicae dahurica, Cynanchum paniculatum and Glycyrrhiza uralensis. CFC is widely used as clinical therapy against rheumatoid arthritis. However, its exact mechanism of action has not been explored yet.
In order to explore the synergistic mechanism of CFC, we designed a study adopting network pharmacology scheme to screen the action targets in relation to the CFC components. The study analyses target facts of salicin, paeonol, liquiritin and imperatorin from PubMed database, and explores the potential pharmacological targets of rheumatoid arthritis, cervical neuralgia and sciatica related diseases for their interaction.
The results of boosted metabolic pathway showed that the chemical components of CFC interrupted many immune-related pathways, thus participating in immunity regulation of the body and playing a role in the treatment of rheumatism. Collectively, CFC has apoptotic, oxidative stress modulatory and anti-inflammatory effects that accumulatively serve for its clinical application against rheumatoid arthritis.
Conclusively, our findings from present study reconnoiters and compacts systematic theoretical approach by utilizing the network pharmacology mechanism of four effective components for the treatment of rheumatism indicating sufficient potential drug targets associated with CFC against rheumatism. These interesting findings entreaties for further in vitro and in vivo studies on the mechanism of compound active ingredient against rheumatism.
复方风湿定胶囊（CFC）是一种源自草药的中药配方，包含八角枫、白芷、徐长卿和甘草。CFC 被广泛用于类风湿关节炎的临床治疗。然而，其确切的作用机制尚未得到探索。
为了探索 CFC 的协同作用机制，我们设计了一项研究，采用网络药理学方案筛选与 CFC 成分相关的作用靶点。该研究分析了来自 PubMed 数据库的水杨苷、丹皮酚、甘草苷和欧前胡素的靶事实，并探讨了类风湿关节炎、颈椎病和坐骨神经痛相关疾病的潜在药理靶点及其相互作用。
增强代谢途径的结果表明，CFC 的化学成分中断了许多与免疫相关的途径，从而参与了机体的免疫调节，在治疗风湿性疾病方面发挥作用。总的来说，CFC 具有凋亡、氧化应激调节和抗炎作用，这些作用累积起来使其在治疗类风湿关节炎方面具有临床应用价值。
综上所述，我们的研究结果通过利用四种有效成分治疗风湿的网络药理学机制，对复方治疗风湿的系统理论方法进行了梳理和整合，为 CFC 治疗风湿提供了足够的潜在药物靶点。这些有趣的发现呼吁进一步开展关于复方活性成分抗风湿作用的体外和体内研究。
