Peng Zhiyong, Guo Xuwen, Xu Weitao, Li Jian, Deng Pengchi, Xiao Xin, Feng Wen, Yuan Lihua
College of Chemistry, Key Laboratory for Radiation Physics and Technology of Ministry of Education, Analytical & Testing Center, Sichuan University, Chengdu 610064, Sichuan, China.
Chem Commun (Camb). 2019 Apr 18;55(33):4869-4872. doi: 10.1039/c9cc00925f.
Three new hydrogen-bonded aromatic amide macrocycles with eight residues were synthesized. The first single crystal structure of this class of larger macrocycles was obtained, which reveals a saddle-like conformation. Interestingly, in sharp contrast to previous negative cooperativity in binding paraquat with cyclo[6]aramide, strong positive allosteric cooperativity in ternary complexes was observed. This may open an avenue for the construction of mechanically interlocked molecules with these larger H-bonded macrocycles.
合成了三种具有八个残基的新型氢键连接的芳族酰胺大环化合物。获得了这类较大大环化合物的首个单晶结构，其呈现出鞍状构象。有趣的是，与之前环[6]芳酰胺与百草枯结合时的负协同效应形成鲜明对比，在三元复合物中观察到了强烈的正变构协同效应。这可能为用这些较大的氢键连接大环构建机械互锁分子开辟一条途径。
