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相似文献

1
Aspirin and gastrointestinal bleeding.阿司匹林与胃肠道出血
J Natl Med Assoc. 1978 Oct;70(10):761-2.
2
Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen.预防感染幽门螺杆菌且正在服用低剂量阿司匹林或萘普生的患者上消化道出血复发。
N Engl J Med. 2001 Mar 29;344(13):967-73. doi: 10.1056/NEJM200103293441304.
3
Aspirin and gastrointestinal toxicity.阿司匹林与胃肠道毒性。
Anadolu Kardiyol Derg. 2007 Dec;7 Suppl 2:27-30.
4
Risk of aspirin-associated major upper-gastrointestinal bleeding with enteric-coated or buffered product.肠溶包衣或缓冲剂型阿司匹林相关的严重上消化道出血风险。
Lancet. 1996 Nov 23;348(9039):1413-6. doi: 10.1016/S0140-6736(96)01254-8.
5
Striking prevalence of over-the-counter nonsteroidal anti-inflammatory drug use in patients with upper gastrointestinal hemorrhage.上消化道出血患者使用非处方非甾体抗炎药的惊人流行率。
Arch Intern Med. 1994 Jan 10;154(1):42-6.
6
Incidence of gastrointestinal bleeding in patients with cardiovascular disease: buffered aspirin versus enteric-coated aspirin.心血管疾病患者胃肠道出血的发生率：缓冲阿司匹林与肠溶阿司匹林的比较。
Scand J Gastroenterol. 2011 Jul;46(7-8):803-9. doi: 10.3109/00365521.2011.568522. Epub 2011 Apr 19.
7
Non-steroidal anti-inflammatory drugs and gastrointestinal bleeding.非甾体抗炎药与胃肠道出血
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8
Gastrointestinal bleeding during low-dose aspirin administration for prevention of arterial occlusive events. A critical analysis.
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9
Is ticlopidine a safe alternative to aspirin for management of myeloproliferative disorders?噻氯匹定在治疗骨髓增殖性疾病方面是阿司匹林的安全替代药物吗？
Haematologica. 1993 Nov-Dec;78(6 Suppl 2):18-21.
10
Optimal drug therapy after aspirin-induced upper gastrointestinal bleeding.阿司匹林致上消化道出血后的最佳药物治疗。
Eur J Intern Med. 2012 Apr;23(3):227-30. doi: 10.1016/j.ejim.2011.10.004. Epub 2011 Nov 4.

本文引用的文献

1
Salicylate damage to the gastric mucosal barrier.水杨酸盐对胃黏膜屏障的损害。
N Engl J Med. 1967 Jun 8;276(23):1307-12. doi: 10.1056/NEJM196706082762308.
2
Editorial: The side effects of aspirin.社论：阿司匹林的副作用
N Engl J Med. 1974 May 23;290(21):1196-7. doi: 10.1056/NEJM197405232902111.
3
Aspirin use in patients with major upper gastrointestinal bleeding and peptic-ulcer disease. A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center.阿司匹林在患有严重上消化道出血和消化性溃疡疾病患者中的应用。波士顿大学医学中心波士顿合作药物监测项目的一份报告。
N Engl J Med. 1974 May 23;290(21):1158-62. doi: 10.1056/NEJM197405232902102.

阿司匹林与胃肠道出血

Aspirin and gastrointestinal bleeding.

作者信息

Krantz J C

出版信息

J Natl Med Assoc. 1978 Oct;70(10):761-2.

PMID:309511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2537102/
Abstract

There is no other over-the-counter (OTC) drug having the widespread use of aspirin. Evoking the well-established analgesic, antipyretic, and anti-inflammatory activities with an amazingly low degree of toxicity, its use has increased in this country to the astounding figure of more than 20 tons daily. The observation that comparatively small daily doses of aspirin may serve as a means of preventing certain types of cardiovascular disasters may lead to even more widespread use of the drug. The most frequent untoward side effect of aspirin is gastric discomfort with or without microbleeding. The amount of bleeding is usually quite small but owing to the long interest of the author in buffered aspirin, it is prudent to determine whether or not this action of aspirin is serious.

摘要

没有其他非处方药（OTC）能像阿司匹林这样被广泛使用。它具有公认的止痛、退热和抗炎作用，且毒性极低，在我国其用量已增至惊人的每日20多吨。有观察表明，相对小剂量的阿司匹林每日服用可能有助于预防某些类型的心血管疾病，这可能会使该药物的使用更加广泛。阿司匹林最常见的不良副作用是胃部不适，可能伴有或不伴有轻微出血。出血量通常很少，但鉴于作者长期关注缓冲阿司匹林，谨慎判断阿司匹林的这种作用是否严重是有必要的。